Skip to Content
Merck
All Photos(6)

Key Documents

View All Documentation

E8875

Sigma-Aldrich

17β-Estradiol

≥98% (HPLC), powder, estrogenic hormone

Synonym(s):

1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin

Sign Into View Organizational & Contract Pricing

Select a Size

250 MG
CZK 926.00
1 G
CZK 2,770.00
5 G
CZK 11,000.00
25 G
CZK 37,300.00
100 G
CZK 115,200.00

CZK 926.00

Please contact Customer Service for Availability
Request a Bulk Order
All Photos(6)

Select a Size

Change View
250 MG
CZK 926.00
1 G
CZK 2,770.00
5 G
CZK 11,000.00
25 G
CZK 37,300.00
100 G
CZK 115,200.00

About This Item

Empirical Formula (Hill Notation):
C18H24O2
CAS Number:
50-28-2
Molecular Weight:
272.38
Beilstein:
1914275
EC Number:
200-023-8
MDL number:
MFCD00003693
UNSPSC Code:
12352104
PubChem Substance ID:
24278426
NACRES:
NA.77

CZK 926.00

Please contact Customer Service for Availability
Request a Bulk Order

Product Name

β-Estradiol, ≥98%

biological source

synthetic (organic)

Quality Level

300

sterility

non-sterile

Assay

≥98%

form

powder

technique(s)

cell culture | mammalian: suitable

mp

176-180 °C (lit.)

solubility

ethanol: 50 mg/mL, clear, colorless

shipped in

ambient

storage temp.

room temp

SMILES string

O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C

InChI

1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

InChI key

VOXZDWNPVJITMN-ZBRFXRBCSA-N

Gene Information

human ... ESR1(2099) , ESR2(2100) , ESRRA(2101) , ESRRB(2103) , GPER(2852) , SERPINA6(866)
mouse ... Esr1(13982) , Esr2(13983) , Esrra(26379)
rat ... Afp(24177) , Ar(24208) , Esr1(24890) , Esr2(25149) , Shbg(24775)

Looking for similar products? Visit Product Comparison Guide

General description

β-Estradiolis a natural steroid estrogen[1] and a female sex hormone.[2] It is an essential component of the female menstrual cycle and plays an important role in the growth and maintenance of the reproductive system.[2]

Application

β-Estradiol has been used:
  • for the in vitro maturation of bovine cumulus-oocyte complexes (COCs)[3]
  • as a supplement in in vitro maturation medium (IVM), which is used as a control medium[4]
  • in estrogen-induction assay[5]

Biochem/physiol Actions

The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) and Nuclear Receptors (Steroids) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

related product

Product No.
Description
Pricing

Pictograms

Health hazardEnvironment
GHS08,GHS09

Signal Word

Danger

Hazard Statements

H351,H360FD,H362,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000382029
0000382022
0000382024
0000382026
0000374949

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Three-step in vitro maturation culture of bovine oocytes imitating temporal changes of estradiol-17beta and progesterone concentrations in preovulatory follicular fluid.
Matsuo M, et al.
Archives Animal Breeding, 60(4), 385-390 (2017)
Supra molecular mechanism of the removal of 17-beta-estradiol endocrine disturbing pollutant from water on functionalized iron nano particles
Ali I, et al.
Journal of Molecular Liquids, 241, 123-129 (2017)
Synthesis and electrochemical characterization of nanostructured magnetic molecularly imprinted polymers for 17-beta-Estradiol determination
Lahcen A, et al.
Sensors and Actuators B, Chemical, 241, 698-705 (2017)
Natriuretic peptide receptor 2 (NPR2) localized in bovine oocyte underlies a unique mechanism for C-type natriuretic peptide (CNP)-induced meiotic arrest.
Xi G, et al.
Theriogenology, 106, 198-209 (2018)
X Xue et al.
Oncogene, 35(21), 2746-2755 (2015-09-15)
Tamoxifen, an estrogen receptor (ER) antagonist, is the mainstay treatment of breast cancer and the development of resistance represents a major obstacle for a cure. Although long non-coding RNAs such as HOTAIR have been implicated in breast tumorigenesis, their roles
View All Related Papers

Questions

  1. Which of the two options, E1024 or E8875, is preferable for use as 1) an oral supplement and 2) silastic tube release? Additionally, among these which one is better for dissolving estrogen in sesame oil.

    1 answer

    1. The in vivo application is beyond the scope of product characterization efforts. However, for the specified applications, E8875 is highly recommended, as it has been well cited in the literature. The following publications may be of interest for protocol reference:

      1. J Vis Exp. 2012 Jun 7;(64):e4013. Ovariectomy and 17β-estradiol replacement in rats and mice: a visual demonstration. PMID: 22710371

      2. Am J Physiol Regul Integr Comp Physiol. 2009 Sep;297(3):R587-92. Loss of ovarian function in the VCD mouse-model of menopause leads to insulin resistance and a rapid progression into the metabolic syndrome. PMID: 19439618

      3. Eur J Pharmacol. 2021 May 25;906:174175. Apigenin acts as a partial agonist action at estrogen receptors in vivo. PMID: 34048736

      Helpful?

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service