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Merck

E8031

Esmolol hydrochloride

≥98% (HPLC), β1 adrenoceptor antagonist , solid

Synonym(s):

4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzenepropanoic acid methyl ester hydrochloride hydrochloride

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10 MG

CZK 3,570.00

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CZK 15,200.00

CZK 3,570.00

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About This Item

Empirical Formula (Hill Notation):
C16H26NClO4
CAS Number:
81161-17-3
Molecular Weight:
331.83
UNSPSC Code:
12352200
PubChem Substance ID:
329799075
NACRES:
NA.77
MDL number:
MFCD00941432
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
desiccated

Key Documents

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Product Name

Esmolol hydrochloride, ≥98% (HPLC), solid

SMILES string

Cl.COC(=O)CCc1ccc(OCC(O)CNC(C)C)cc1

InChI

1S/C16H25NO4.ClH/c1-12(2)17-10-14(18)11-21-15-7-4-13(5-8-15)6-9-16(19)20-3;/h4-5,7-8,12,14,17-18H,6,9-11H2,1-3H3;1H

InChI key

GEKNCWBANDDJJL-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

mp

89.0-90.6 °C

solubility

H2O: 12 mg/mL

originator

Baxter

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... ADRB1(153), ADRB2(154)

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Show Differences

1 of 4

This Item
1249701SML1785SML1569
Esmolol hydrochloride ≥98% (HPLC), solid

Sigma-Aldrich

E8031

Esmolol hydrochloride

Esmolol hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1249701

Esmolol hydrochloride

Landiolol hydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML1785

Landiolol hydrochloride

Acotiamide dihydrochloride ≥98% (HPLC)

Sigma-Aldrich

SML1569

Acotiamide dihydrochloride

form

solid

form

-

form

powder

form

powder

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

H2O: 12 mg/mL

solubility

-

solubility

H2O: 25 mg/mL, clear

solubility

H2O: 20 mg/mL, clear

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

desiccated

Application

Esmolol hydrochloride (ESM) may be used as a standard in spectrophotometric and electrochemical method for the determination of ESM in biological samples and pharmaceutical formulations.

Biochem/physiol Actions

Esmolol hydrochloride is a ultrashort-acting β1 adrenoceptor antagonist (β1 receptor occupancy = 84.7%).
Esmolol hydrochloride (ESM) is a class II antiarrhythmic drug. It is used to decrease the force and rate of heart contractions during surgery. Overdose of ESM can lead to side effects such as bradycardia, cardiac arrest, hypoventilation, mood disorder, and coma.

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000463574
0000463574
0000445438
0000445438
0000441966

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Electrochemical System for Determination of Esmolol Hydrochloride Using Square Wave Adsorptive Stripping Voltammetry
Alarfaj NA and El-Tohamy MF
International Journal of Electrochemical Science (2016)
Spectrophotometric determination of esmolol hydrochloride using analytical reagents
Narayana A, et al.
Indian Journal of Advances in Chemical Science null
George Dimopoulos et al.
The Journal of surgical research, 198(1), 175-184 (2015-06-16)
Based on previous animal studies showing promising immunomodulatory efficacy esmolol, a selective β1-blocker, it was assumed that administration of esmolol in experimental pyelonephritis by multidrug-resistant Pseudomonas aeruginosa would prolong survival and modulate immune response. Acute pyelonephritis was induced in 80
Yong-Feng Zhu et al.
Journal of laparoendoscopic & advanced surgical techniques. Part A, 25(11), 903-907 (2015-11-18)
To determine the effect of lavage with adrenaline solution on CO2 absorption during retroperitoneal laparoscopic surgery. Sixty patients scheduled to undergo retroperitoneal laparoscopic surgery were divided into an AD group (lavage with normal saline containing adrenaline [1:500,000], n = 30)

Articles

β-Adrenoceptors

β-Adrenoceptors are activated either by norepinephrine or epinephrine. Learn more about the role of β-adrenoceptors in protein expression, cell signaling, and metabolism research.

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