It is recommended to prepare solutions fresh.
E3763
Resorufin ethyl ether
≥98% (TLC), CXPIA1/2 substrate, powder
Synonym(s):
7-Ethoxy-3H-phenoxazin-3-one, Ethoxyresorufin, O7-Ethylresorufin
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Select a Size
1 MG
CZK 2,520.00
5 MG
CZK 8,520.00
About This Item
Empirical Formula (Hill Notation):
C14H11NO3
CAS Number:
Molecular Weight:
241.24
NACRES:
NA.47
PubChem Substance ID:
UNSPSC Code:
12161501
MDL number:
Beilstein/REAXYS Number:
225973
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Product Name
Resorufin ethyl ether, ≥98% (TLC), powder
InChI
1S/C23H14F5NO4.C14H11NO3/c24-17-18(25)20(27)22(21(28)19(17)26)33-16(30)9-29-23(31)32-10-15-13-7-3-1-5-11(13)12-6-2-4-8-14(12)15;1-2-17-10-4-6-12-14(8-10)18-13-7-9(16)3-5-11(13)15-12/h1-8,15H,9-10H2,(H,29,31);3-8H,2H2,1H3
SMILES string
CCOc1ccc2N=C3C=CC(=O)C=C3Oc2c1.Fc4c(F)c(F)c(OC(=O)CNC(=O)OCC5c6ccccc6-c7ccccc57)c(F)c4F
InChI key
ZOSYTBPPLWBBKM-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
storage condition
(Tightly closed. Dry)
technique(s)
activity assay: suitable
color
orange to red
mp
223-225 °C (lit.)
solubility
chloroform: 9.80-10.20 mg/mL, clear, orange
suitability
suitable for fluorescence
storage temp.
−20°C
Quality Level
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Related Categories
1 of 4
This Item | |||
|---|---|---|---|
| assay ≥98% (TLC) | assay ≥98.0% (HPLC) | assay ≥95% (UV) | assay ≥98% (TLC) |
| technique(s) activity assay: suitable | technique(s) - | technique(s) - | technique(s) - |
| suitability suitable for fluorescence | suitability - | suitability suitable for fluorescence | suitability - |
| solubility chloroform: 9.80-10.20 mg/mL, clear, orange | solubility dichloromethane: 0.95-1.05 mg/mL, clear, orange to very deep orange | solubility DMF: soluble, DMSO: soluble, alcohols: soluble | solubility acetonitrile: 0.95- 1.05 mg/mL, clear, orange |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 200 |
| form powder | form powder | form solid | form powder |
General description
Fluorimetric substrate for cytochrome P450 linked enzyme, CXPIA1/2
Resorufin ethers are used as markers or substrates for different cytochrome P (CYP) isoforms. Resorufin ethyl ether is the preferred resorufin ether to be metabolized by microsomes of 3-methylcholanthrene treated animals.[1]
Resorufin is the reduced product of resazurin, also termed as Alamar Blu. It exhibits fluorescence at longer wavelengths and is flexible for modification in its hydroxyl group.
Research area: Cell Signaling
Research area: Cell Signaling
Application
Resorufin ethyl ether is suitable for the study of dealkylating activity of cytochrome P450 isozymes 1A1 and 1A2, where arylalkyl and alkyl isothiocyanates, and their glutathione, cysteine, and A′-acetylcysteine conjugates are used as inhibitors.[2] It is suitable to study the ethoxyresorufin-O-deethylase (EROD) activity of cytochrome P450 activity (CYP1A1).[3]
used together
Product No.
Description
Pricing
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Reduction of resazurin to resorufin catalyzed by gold nanoparticles: dramatic reaction acceleration by laser or LED plasmon excitation
Alejo CJ, et al.
Catalysis Science & Technology, 1(8), 1506-1511 (2011)
C C Conaway et al.
Carcinogenesis, 17(11), 2423-2427 (1996-11-01)
A series of arylalkyl and alkyl isothiocyanates, and their glutathione, cysteine, and N-acetylcysteine conjugates were used to study their inhibitory activity toward the dealkylation of ethoxyresorufin (EROD), pentoxyresorufin (PROD), and methoxyresorufin (MROD) in liver microsomes obtained from the 3-methylcholanthrene or
V Villa-Cruz et al.
Chemosphere, 74(9), 1145-1151 (2009-01-16)
Tilapia fish (Oreochromis niloticus) were fed with enriched diets containing broccoli and its phytochemical sulforaphane over 30 d. The levels of cytochrome P450, superoxide dismutase, catalase, lipid peroxidation and glutathione-S-transferase activities were measured. Basal value of cytochrome P450 activity was
T E M Parente et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 150(2), 252-260 (2009-05-23)
We investigated the presence and inducibility of CYP1A in suckermouth catfish (Hypostomus affinis and Hypostomus auroguttatus, Loricariidae), tilapia (Oreochromis niloticus, Cichlidae) and mice (Mus musculus, Muridae). Alkoxyresorufin-O-dealkylases (EROD, MROD, PROD and BROD) were detected and proved to be inducible (beta-naphthoflavone
Shotaro Uehara et al.
The Journal of pharmacology and experimental therapeutics, 339(2), 654-661 (2011-08-19)
The cynomolgus monkey is widely used as a primate model in preclinical studies because of its evolutionary closeness to humans. Despite their importance in drug metabolism, the content of each cytochrome P450 (P450) enzyme has not been systematically determined in
Articles
Phase I biotransformation reactions increase drug compound polarity, mainly occurring in hepatic circulation.
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