E1379

7-Ethoxycoumarin

Name: 7-Ethoxycoumarin
Brand: SIGMA
Price: 755 CZK

≥99.45% (HPLC), CYP450 substrate, powder

Synonym(s):

7-Ethoxy-1-benzopyran-2-one

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₀O₃

CAS Number:

31005-02-4

Molecular Weight:

190.20

NACRES:

NA.77

PubChem Substance ID:

24894404

UNSPSC Code:

12161501

EC Number:

250-429-4

MDL number:

MFCD00006877

Beilstein/REAXYS Number:

146200

Assay:

≥99.45% (HPLC)

Form:

powder

Quality level:

200

Key Documents

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Product Name

7-Ethoxycoumarin,

assay

≥99.45% (HPLC)

Quality Level

200

form

powder

mp

88-90 °C (lit.)

solubility

95% ethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

fluorescence

λ_ex 323 nm; λ_em 386 nm

SMILES string

CCOc1ccc2C=CC(=O)Oc2c1

InChI

1S/C11H10O3/c1-2-13-9-5-3-8-4-6-11(12)14-10(8)7-9/h3-7H,2H2,1H3

InChI key

LIFAQMGORKPVDH-UHFFFAOYSA-N

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Show Differences

1 of 4

This Item	UC283	A9861	D7910
Sigma-Aldrich E1379 7-Ethoxycoumarin	Sigma-Aldrich UC283 7-Hydroxycoumarin sulfate potassium salt	Sigma-Aldrich A9861 Auraptene	D7910 3,4-Dichloroisocoumarin
form powder	form solid	form powder	form powder
assay ≥99.45% (HPLC)	assay ≥95% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (TLC)
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 200
solubility 95% ethanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow	solubility H₂O: soluble, methanol: soluble	solubility DMSO: >20 mg/mL	solubility ethyl acetate: 49.00-51.00 mg/mL, clear, colorless to faintly yellow
mp 88-90 °C (lit.)	mp 204-205 °C	mp -	mp -
fluorescence λ_ex 323 nm; λ_em 386 nm	fluorescence -	fluorescence -	fluorescence -

Application

7-Ethoxycoumarin has been used to study the functional activity of recombinant P450. ) It has also been used as an internal standard for in vitro S-warfarin 7-hydroxylation and high performance liquid chromatography (HPLC) analysis.

Biochem/physiol Actions

7-Ethoxycoumarin is a cytochrome P450 substrate.[1]

Substrate for CYP2B6

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Functional characterization of human CYP2C9 allelic variants in COS-7 cells

Du H, et al.

Frontiers in Pharmacology, 7, 98-98 (2016)

Systematic screening of Escherichia coli single-gene knockout mutants for improving recombinant whole-cell biocatalysts.

Ying Zhou et al.

Applied microbiology and biotechnology, 87(2), 647-655 (2010-03-13)

Systematic screening of single-gene knockout collection of Escherichia coli BW25113 (the Keio collection) was performed to select mutants that could enhance the deethylation of 7-ethoxycoumarin catalyzed by CYP154A1. After 96-well plate high-throughput screening followed by test tube assays, four mutants

Silkworm as a model animal to evaluate drug candidate toxicity and metabolism.

Hiroshi Hamamoto et al.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 149(3), 334-339 (2008-09-23)

To evaluate the feasibility of using the silkworm as a model animal for screening drug candidates, we examined whether the lethal dose of cytotoxic chemicals in silkworm, Bombyx mori, were consistent with those in mammals, and compared the metabolic pathways

Generation of human metabolites of 7-ethoxycoumarin by bacterial cytochrome P450 BM3.

Dong-Hyun Kim et al.

Drug metabolism and disposition: the biological fate of chemicals, 36(11), 2166-2170 (2008-08-02)

Recently, wild-type and mutant forms of bacterial cytochrome P450 BM3 (CYP102A1) have been found to metabolize various drugs through reactions similar to those catalyzed by human cytochromes P450 (P450s). Therefore, it has been suggested that CYP102A1 may be used to

Unravelling the molecular determinants of bee sensitivity to neonicotinoid insecticides

Manjon C, et al.

Current Biology, 28(7), 1137-1143 (2018)

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Global Trade Item Number

SKU	GTIN
E1379-1G	04061826709313
E1379-25MG	04061833460986
E1379-500MG	04061833601730
E1379-100MG	04061833601723

Questions

Anonymous

4 months ago

Hello, there is no storage temperature information on the CofA, SDS, or product label for product E1379, 7-Ethoxycoumarin. Can you please confirm? Thank you

1 answer

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7-Ethoxycoumarin