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E0881

Sigma-Aldrich

Elastatinal

powder

Synonym(s):

(2S)-2-[(4S)-2-Amino-1,4,5,6-tetrahydro4-pyrimidinyl]-N-[[[(1S)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-N1-[(1S)-1-methyl-2-oxoethyl-L-glutamamide

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5 MG
CZK 4,660.00
10 MG
CZK 8,500.00
25 MG
CZK 12,320.00

CZK 4,660.00

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5 MG
CZK 4,660.00
10 MG
CZK 8,500.00
25 MG
CZK 12,320.00

About This Item

Empirical Formula (Hill Notation):
C21H36N8O7
CAS Number:
51798-45-9
Molecular Weight:
512.56
Beilstein:
873543
EC Number:
257-426-7
MDL number:
MFCD00151180
UNSPSC Code:
12352202
PubChem Substance ID:
24894375
NACRES:
NA.77

CZK 4,660.00

Please contact Customer Service for Availability
Request a Bulk Order

Product Name

Elastatinal, microbial

biological source

microbial

form

powder

solubility

water: 20 mg/mL, clear, faintly yellow to yellow

storage temp.

−20°C

SMILES string

[H]C(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)N[C@@H](CC(C)C)C(O)=O)[C@]1([H])CCNC(=N)N1

InChI

1S/C21H36N8O7/c1-10(2)8-14(19(34)35)28-21(36)29-16(12-6-7-24-20(23)27-12)18(33)26-13(4-5-15(22)31)17(32)25-11(3)9-30/h9-14,16H,4-8H2,1-3H3,(H2,22,31)(H,25,32)(H,26,33)(H,34,35)(H3,23,24,27)(H2,28,29,36)/t11-,12-,13-,14-,16-/m0/s1

InChI key

IJWCGVPEDDQUDE-YGJAXBLXSA-N

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Related Categories

Biochem/physiol Actions

Potent, irreversible elastase inhibitor.
Potent, irreversible elastase inhibitor. Elastatinal is a much stronger inhibitor of elastase from pancreas than from leucocytes.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW8515
MKCV6276
MKCS8836
MKCR6040
MKCQ4656

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De-Peng Jiang et al.
Journal of Korean medical science, 26(6), 778-784 (2011-06-10)
Scutellarin is a flavonoid extracted from a traditional Chinese herb, Erigeron breviscapus. The present study investigated the effect of scutellarin on MUC5AC mucin production and the possible mechanism. Human bronchial epithelial 16 (HBE16) cells were pretreated with scutellarin for 60
Sandra Cerqueira Barros et al.
Enzyme and microbial technology, 50(2), 107-114 (2012-01-10)
Elastase plays an important role in wound healing process, degrading damaged tissue and allowing complete tissue recovery. The levels of human neutrophil elastase (HNE) are usually controlled by endogenous inhibitors. However, in the presence of high levels of elastase, like
T Yagi et al.
Cancer letters, 10(4), 301-307 (1980-10-01)
Effects of elastatinal, a protease inhibitor, on DNA repair and its cytotoxicity were investigated in normal human, xeroderma pigmentosum and Chinese hamster V79 cells. There were no effects of elastatinal on DNA repair and UV-induced sister chromatid exchanges, and all
P Paul et al.
Carcinogenesis, 2(4), 255-259 (1981-01-01)
Microbial protease inhibitors elastatinal and leupeptin were tested for cytotoxicity and for effects on spontaneous and u.v.-induced 6-thioguanine-resistant (6TGr) mutation and sister-chromatid exchange (SCE) in V79 Chinese hamster cells. Continuous treatment with elastatinal exhibited marked cytotoxicity, while leupeptin was almost
Valentina Grano et al.
Biotechnology progress, 20(3), 968-974 (2004-06-05)
The inhibitory power of three different active Nylon membranes, separately loaded with three different protease inhibitors, was studied with the aim of reducing the increased elastase concentration occurring during hemodialysis or extracorporeal blood circulation in patients undergoing cardiopulmonary bypass. Chemical
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