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D9160

1-Deoxymannojirimycin hydrochloride

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Synonym(s):

1-Deoxymannojirimycin HCl, 1,5-Dideoxy-1,5-imino-D-mannitol hydrochloride

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5 mg
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9 060,00 CZK
10 mg
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17 600,00 CZK
13 200,00 CZK

About This Item

Empirical Formula (Hill Notation):
C6H13NO4 · HCl
CAS Number:
73465-43-7
Molecular Weight:
199.63
NACRES:
NA.76
PubChem Substance ID:
24894265
UNSPSC Code:
51102829
MDL number:
MFCD00083611

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form

powder

Quality Segment

color

white to off-white

solubility

H2O: 10 mg/mL

antibiotic activity spectrum

viruses

mode of action

enzyme | inhibits

storage temp.

2-8°C

SMILES string

Cl.OC[C@H]1NC[C@@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4-,5-,6-;/m1./s1

InChI key

ZJIHMALTJRDNQI-MVNLRXSJSA-N

General description

Chemical structure: glucosamine

Application

1-Deoxymannojirimycin (DMM) hydrochloride is an inhibitor of N-linked glycosylation and has antiviral activity. Derivatives of deoxymannojirimycin may have anti-HIV activity. It has been used for treatment of T lymphocytes and to study it′s effect on allogeneic cytotoxic T lymphocytes (CTL). It is used for studies on Golgi-mediated glycoprotein processing.

Biochem/physiol Actions

1-Deoxymannojirimycin is a mannosidase I inhibitor, alters cell-surface complex carbohydrate structure as assayed by PHA-L binding, and increases high mannose structures as indicated by the increased Con-A binding.
Selectively inhibits Golgi associated α(1→2) mannosidase and for studies on Golgi-mediated glycoprotein processing.

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This Item
D9305P9620S9007
1-Deoxymannojirimycin hydrochloride

Sigma-Aldrich

D9160

1-Deoxymannojirimycin hydrochloride

1-Deoxynojirimycin hydrochloride

Sigma-Aldrich

D9305

1-Deoxynojirimycin hydrochloride

Puromycin dihydrochloride Ready Made Solution, from Streptomyces alboniger, 10 mg/mL in H2O, suitable for cell culture

Sigma-Aldrich

P9620

Puromycin dihydrochloride

Spectinomycin dihydrochloride pentahydrate potency: ≥603 μg per mg

Sigma-Aldrich

S9007

Spectinomycin dihydrochloride pentahydrate

description

-

description

-

description

Ready Made Solution, from Streptomyces alboniger, 10 mg/mL in H2O, suitable for cell culture

description

potency: ≥603 μg per mg

antibiotic activity spectrum

viruses

antibiotic activity spectrum

viruses

antibiotic activity spectrum

neoplastics, Gram-positive bacteria, parasites

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

enzyme | inhibits

mode of action

enzyme | inhibits

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

200

form

powder

form

powder

form

ready-to-use solution

form

powder

solubility

H2O: 10 mg/mL

solubility

water: 19.60-20.40 mg/mL, clear, colorless

solubility

H2O: soluble 10 mg/mL

solubility

H2O: soluble 50 mg/mL

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Codes

H302 + H312 + H332

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

WGK

WGK 3

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

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    Lot/Batch Number
    0000564158
    0000087394
    0000116857
    0000506793
    0000202339

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