D8446

P7C3

≥98% (HPLC)

• Synonym(s): 3,6-Dibromo-a-[(phenylamino)methyl]-9H-carbazole-9-ethanol
• Empirical Formula (Hill Notation): C₂₁H₁₈Br₂N₂O
• CAS Number: 301353-96-8
• Molecular Weight: 474.19
• MDL number: MFCD00572918
• UNSPSC Code: 12352203
• PubChem Substance ID: 329798864
• NACRES: NA.25

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: DMSO: 34 mg/mL
• storage temp.: 2-8°C
• SMILES string: OC(CNc1ccccc1)Cn2c3ccc(Br)cc3c4cc(Br)ccc24
• InChI: 1S/C21H18Br2N2O/c22-14-6-8-20-18(10-14)19-11-15(23)7-9-21(19)25(20)13-17(26)12-24-16-4-2-1-3-5-16/h1-11,17,24,26H,12-13H2
• InChI key: FZHHRERIIVOATI-UHFFFAOYSA-N

Description

Application

P7C3 is an aminopropyl carbazole agent with proneurogenic and neuroprotective properties in newborn neural precursor cells of the dentate gyrus. Its analogs may be used in neurodegenerative disease research to study the process of neurogenesis in brain regions such as the subgranular zone of the hippocampal dentate gyrus.[1] P7C3 and its analogs may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as potential drug for the treatment of condition such as Alzheimer′s disease, Parkinson′s disease, amyotrophic lateral sclerosis and traumatic brain injury.[2]

Biochem/physiol Actions

P7C3 is a proneurogenic, neuroprotective enhancer of neuron formation.

P7C3 is neurogenic and protects new neurons against apoptosis. These activities may be related to its capacity to protect mitochondrial integrity.

Degeneration of the hippocampus is an early manifestation of Alzheimer′s disease. P7C3 promotes neurogenesis in the subgranular zone of the hippocampal dentate gyrus, the site of normal neurogenesis in adult mammals, making it an important lead compound in development of new Alzheimer′s treatments.

Safety Information

• Pictograms: GHS06,GHS05
• Signal Word: Danger
• Hazard Statements: H301,H318
• Precautionary Statements: P264 - P280 - P301 + P310 - P305 + P351 + P338 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Eye Dam. 1
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable