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D8147

Dynorphin A porcine

≥95% (HPLC)

Synonym(s):

Dynorphin-(1-17)

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About This Item

Empirical Formula (Hill Notation):
C99H155N31O23
CAS Number:
80448-90-4
Molecular Weight:
2147.48
NACRES:
NA.32
PubChem Substance ID:
24894194
UNSPSC Code:
51111800
MDL number:
MFCD00076351

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InChI

1S/C99H155N31O23/c1-7-55(6)81(129-86(142)66(28-18-40-112-98(107)108)118-83(139)65(27-17-39-111-97(105)106)120-88(144)70(44-54(4)5)125-89(145)71(46-56-21-9-8-10-22-56)117-79(135)52-115-78(134)51-116-82(138)61(102)45-57-31-33-59(131)34-32-57)94(150)122-67(29-19-41-113-99(109)110)95(151)130-42-20-30-75(130)93(149)121-64(26-14-16-38-101)85(141)124-69(43-53(2)3)87(143)119-63(25-13-15-37-100)84(140)126-72(47-58-50-114-62-24-12-11-23-60(58)62)90(146)128-74(49-80(136)137)92(148)127-73(48-77(104)133)91(147)123-68(96(152)153)35-36-76(103)132/h8-12,21-24,31-34,50,53-55,61,63-75,81,114,131H,7,13-20,25-30,35-49,51-52,100-102H2,1-6H3,(H2,103,132)(H2,104,133)(H,115,134)(H,116,138)(H,117,135)(H,118,139)(H,119,143)(H,120,144)(H,121,149)(H,122,150)(H,123,147)(H,124,141)(H,125,145)(H,126,140)(H,127,148)(H,128,146)(H,129,142)(H,136,137)(H,152,153)(H4,105,106,111)(H4,107,108,112)(H4,109,110,113)/t55-,61-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,81-/m0/s1

SMILES string

[H]N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)NCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O

InChI key

JMNJYGMAUMANNW-FIXZTSJVSA-N

assay

≥95% (HPLC)

form

powder

UniProt accession no.

P01214, P32300, P33533, P41145

storage temp.

−20°C

Quality Level

200

Gene Information

human ... OPRK1(4986)
mouse ... Oprd1(18386)
pig ... PDYN(445529)
rat ... Oprd1(24613)

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This Item
D7017T0675E7131
Dynorphin A porcine ≥95% (HPLC)

Sigma-Aldrich

D8147

Dynorphin A porcine

Dynorphin A Porcine Fragment 1-13 ≥97% (HPLC)

Sigma-Aldrich

D7017

Dynorphin A Porcine Fragment 1-13

[D-Ala2]-Deltorphin II ≥97% (HPLC)

Sigma-Aldrich

T0675

[D-Ala2]-Deltorphin II

[D-Ala2, D-Leu5]-Enkephalin acetate salt ≥95% (HPLC)

Sigma-Aldrich

E7131

[D-Ala2, D-Leu5]-Enkephalin acetate salt

assay

≥95% (HPLC)

assay

≥97% (HPLC)

assay

≥97% (HPLC)

assay

≥95% (HPLC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder

form

-

Gene Information

human ... OPRK1(4986)
mouse ... Oprd1(18386)
pig ... PDYN(445529)
rat ... Oprd1(24613)

Gene Information

pig ... PDYN(445529)

Gene Information

human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)
mouse ... Oprd1(18386), Oprm1(18390)
rat ... Oprd1(24613), Oprm1(25601)

Gene Information

human ... OPRD1(4985)
mouse ... OPRD1(18386)
rat ... OPRD1(24613)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

UniProt accession no.

P01214, P33533

UniProt accession no.

P01214

UniProt accession no.

-

UniProt accession no.

-

Application

Dynorphin A has been used in immunohistochemistry.

Biochem/physiol Actions

Dynorphin A porcine is an opioid peptide. It is an endogenous κ-agonist that is resistant to enzymatic degradation. Dynorphin A has the ability to decrease calcium current by selectively decreasing the large inactivating (N) calcium current. It can decrease the calcium-dependent action potential duration of DRG (dorsal root ganglion) and myenteric neurons.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SLCR4396
SLCR4396
SLCP6380
SLCC4147
SLBZ2917

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S Zhang et al.
The Journal of pharmacology and experimental therapeutics, 286(1), 136-141 (1998-07-10)
Dynorphin A is an endogenous opioid peptide that activates the kappa opioid receptor (KOR) with high potency. Some studies also showed that the distribution and functional activity of dynorphin A are not completely correlated with those of KOR, suggesting that
S J Shuster et al.
Neuroscience, 96(2), 373-383 (2000-02-23)
The relationship between the cloned kappa opioid receptor, dynorphin, and the neurohypophysial hormones vasopressin and oxytocin was analysed in the guinea-pig hypothalamic magnocellular neurosecretory neurons. This analysis was performed in order to understand better which population of neuroendocrine neurons in
T Naqvi et al.
Peptides, 19(7), 1277-1292 (1998-10-24)
An up-to-date review is presented covering all the available information concerning the isolation, discovery, synthesis, conformation, receptor binding characteristics, pharmacological properties and SAR studies of dynorphin A and related peptides. The potential of dynorphin A and its analogs has yet
Insights into the unique torpor of Botrylloides leachi, a colonial urochordate
Hyams Y, et al.
Developmental Biology, 428(1), 101-117 (2017)
Dynorphin A selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion neurons in cell culture
Gross R A and Macdonald R L
Proceedings of the National Academy of Sciences of the USA, 84(15), 5469-5473 (1987)
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