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Merck

D6500

2′-Deoxyadenosine 5′-triphosphate disodium salt

≥97%

Synonym(s):

dATP-Na2

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10 MG

CZK 3,220.00

25 MG

CZK 5,140.00

100 MG

CZK 13,800.00

CZK 3,220.00

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About This Item

Empirical Formula (Hill Notation):
C10H14N5Na2O12P3
CAS Number:
74299-50-6
Molecular Weight:
535.15
PubChem Substance ID:
24894029
eCl@ss:
32160414
UNSPSC Code:
41106305
NACRES:
NA.51
EC Number:
277-809-2
MDL number:
MFCD00080335
Assay:
≥97%
Biological source:
natural (inorganic)
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
−20°C

Key Documents

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InChI key

JEKDCIBJADJZSK-LNUHRGGJSA-L

InChI

1S/C10H16N5O12P3.2Na/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19;;/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);;/q;2*+1/p-2/t5-,6+,7?;;/m0../s1

SMILES string

[Na+].[Na+].Nc1ncnc2n(cnc12)C3C[C@H](O)[C@@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)O3

biological source

natural (inorganic)

assay

≥97%

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

200

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1 of 4

This Item
D4001D6000A26209
2′-Deoxyadenosine 5′-triphosphate disodium salt ≥97%

Sigma-Aldrich

D6500

2′-Deoxyadenosine 5′-triphosphate disodium salt

2′-Deoxyuridine 5′-triphosphate sodium salt ≥95%

Sigma-Aldrich

D4001

2′-Deoxyuridine 5′-triphosphate sodium salt

2′-Deoxyadenosine 5′-di­phos­phate sodium salt

Sigma-Aldrich

D6000

2′-Deoxyadenosine 5′-di­phos­phate sodium salt

Adenosine 5′-triphosphate disodium salt hydrate 99%

Sigma-Aldrich

A26209

Adenosine 5′-triphosphate disodium salt hydrate

biological source

natural (inorganic)

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

assay

≥97%

assay

≥95%

assay

≥95% (HPLC)

assay

99%

form

powder

form

powder

form

powder

form

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

Application

2′-Deoxyadenosine 5′-triphosphate (dATP) is used as a substrate by a variety of polymerases including DNA polymerase(s) and reverse transcriptase(s).
2′-Deoxyadenosine 5′-triphosphate disodium salt has been used:
  • for Smac- X-linked inhibitor of apoptosis protein (Smac-XIAP) binding assay.
  • as a component of polymerase chain reaction (PCR) using AM-toxin primers.[1]
  • to determine the affinity constant (Kd) with the transcription termination factor Rho.
  • to determine the activity of poly ADP-ribose polymerase 1 (PAPR-1 ).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000537312
0000537312
0000513811
0000513811
0000512512

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Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA
Gemble S, et al.
PLoS Genetics, 11(7), e1005384-e1005384 (2015)
Functional mutation of SMAC/DIABLO, encoding a mitochondrial proapoptotic protein, causes human progressive hearing loss DFNA64
Cheng J, et al.
American Journal of Human Genetics, 89(1), 56-66 (2011)
Michael Trostler et al.
Biochemistry, 48(21), 4633-4641 (2009-04-08)
We used a series of dATP and dGTP analogues to determine how DNA polymerase I from Bacillus stearothermophilus (BF), a prototypical A family polymerase, uses N-1, N(2), N-3, and N(6) of purine dNTPs to differentiate between right and wrong nucleotide
J E Reardon
Biochemistry, 31(18), 4473-4479 (1992-05-12)
Steady-state and pre-steady-state kinetic constants were determined for reverse transcriptase catalyzed incorporation of nucleotides and nucleotide analogues into defined-sequence DNA primed-RNA templates. 3'-Azido-3'-deoxythymidine 5'-triphosphate (AZTTP) was almost as efficient a substrate (kcat/Km) as dTTP for the enzyme. In contrast, the
Fadia Haddad et al.
Methods in molecular biology (Clifton, N.J.), 630, 261-270 (2010-03-20)
Reverse transcription (RT) is the synthesis of complementary deoxyribonucleic acids (DNA) from single-stranded ribonucleic acid (RNA) templates. This process is catalyzed by the reverse transcriptase enzyme, which is the replicating enzyme of retroviruses. Reverse transcriptase was discovered in 1970, and
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