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Merck

D3168

Duramycin from Streptoverticillium cinnamoneus

≥90.0%

Synonym(s):

Duramycin, Lancovutide

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10 MG

CZK 14,600.00

CZK 14,600.00

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About This Item

Empirical Formula (Hill Notation):
C89H125N23O25S3
CAS Number:
1391-36-2
Molecular Weight:
2013.28
UNSPSC Code:
51102829
NACRES:
NA.85
MDL number:
MFCD00133301

Key Documents

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assay

≥90.0%

form

powder

solubility

0.1 M HCl: 10 mg/mL

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

protein synthesis | interferes

storage temp.

2-8°C

Quality Level

200

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This Item
T338387128T3258
Duramycin from Streptoverticillium cinnamoneus ≥90.0%

Sigma-Aldrich

D3168

Duramycin from Streptoverticillium cinnamoneus

Tetracycline hydrochloride ≥95% (European Pharmacopoeia HPLC assay), meets EP testing specifications

Sigma-Aldrich

T3383

Tetracycline hydrochloride

Tetracycline 98.0-102.0% (HPLC)

Sigma-Aldrich

87128

Tetracycline

Tetracycline 98.0-102.0% (HPLC)

Sigma-Aldrich

T3258

Tetracycline

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

mode of action

protein synthesis | interferes

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

powder

form

powder or crystals

form

powder or crystals

assay

≥90.0%

assay

≥95% (European Pharmacopoeia HPLC assay)

assay

98.0-102.0% (HPLC)

assay

98.0-102.0% (HPLC)

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

Chemical structure: tetracycline

Application

Duramycin is used to study chloride secretion by cardial, pancreatic and airway epithelial voltage-gated ion channels. It is used to study cystic fibrosis and as a novel phosphatidylethanolamine-binding molecular probe[1]. It is used to stimulate sodium transport in cultured human colonic epithelia[2].

Biochem/physiol Actions

Duramycin is the smallest known polypeptide since it has only 19 amino acids. It has a defined 3-dimensional binding structure. Duramycin binds phosphatidylethanolamine (PtdE) at a 1:1 ratio with high affinity and exclusive specificity[1]. It enhances chloride secretion in airway epithelium.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000410411
0000410411
0000396599
0000371456
0000339694

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Andrei Marconescu et al.
Biochimica et biophysica acta, 1778(10), 2217-2224 (2008-06-24)
The major anionic phospholipid, phosphatidylserine (PS), and the neutral phospholipid, phosphatidylethanolamine (PE), are largely confined to the inner leaflet of the plasma membrane bilayer in mammalian cells under normal conditions. This asymmetry is lost when cells undergo apoptosis, become activated
M M Cloutier et al.
The American journal of physiology, 259(3 Pt 1), C450-C454 (1990-09-01)
The effect of duramycin, a polypeptide antibiotic, on Cl- transport in canine tracheal epithelium mounted in Ussing chambers was studied. Over a narrow concentration range, duramycin increased short-circuit current (Isc) and net Cl- secretion and had no effect on mannitol
Igor Oliynyk et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 118(12), 982-990 (2010-11-26)
The lantibiotic duramycin (Moli1901, Lancovutide) has been suggested as a drug of choice in the treatment for cystic fibrosis (CF). It has been proposed that duramycin may stimulate chloride secretion through Ca²(+) -activated Cl⁻ channels (CaCC). We investigated whether duramycin
Ming Zhao et al.
Nuclear medicine and biology, 39(7), 1006-1011 (2012-08-04)
(99m)Tc-Duramycin is a unique radiopharmaceutical that binds specifically to phosphatidylethanolamine (PE). The current effort is to develop a single-step kit formulation for the (99m)Tc labeling of HYNIC-Duramycin. A titration series of Tricine/TPPTS coligand systems were tested for an optimal formulation
Soichiro Matsunaga et al.
Langmuir : the ACS journal of surfaces and colloids, 25(14), 8200-8207 (2009-05-13)
We visualized nanometer-scale phospholipid particle fusion by scanning tunneling microscopy (STM) on an alkanethiol-modified gold substrate, induced by duramycin, a tetracyclic antibiotic peptide with 19 amino residues. Ultrasonic homogenization generated a suspension mainly consisting of minimal lipid particles (MLP) from
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