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D0567

DIF-3

≥99% (HPLC), solid

Synonym(s):

1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone, Differentiation-inducing factor 3

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Pack SizeSKUAvailabilityPrice
1 mg
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CZK 3,300.00

About This Item

Empirical Formula (Hill Notation):
C13H17ClO4
CAS Number:
113411-17-9
Molecular Weight:
272.72
NACRES:
NA.77
PubChem Substance ID:
24724455
UNSPSC Code:
12352200
MDL number:
MFCD05865230
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
100

CZK 3,300.00

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Quality Level

100

assay

≥99% (HPLC)

form

solid

solubility

DMSO: soluble 46 mg/mL

SMILES string

CCCCCC(=O)c1c(O)cc(OC)c(Cl)c1O

InChI

1S/C13H17ClO4/c1-3-4-5-6-8(15)11-9(16)7-10(18-2)12(14)13(11)17/h7,16-17H,3-6H2,1-2H3

InChI key

JWBMZIJMSBFBIY-UHFFFAOYSA-N

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This Item
SML0599475846SRP4757
DIF-3 ≥99% (HPLC), solid

Sigma-Aldrich

D0567

DIF-3

DIF-1 ≥98% (HPLC)

Sigma-Aldrich

SML0599

DIF-1

MIF Antagonist III, 4-IPP

Sigma-Aldrich

475846

MIF Antagonist III, 4-IPP

GDF-3 human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Sigma-Aldrich

SRP4757

GDF-3 human

form

solid

form

powder

form

solid

form

lyophilized

assay

≥99% (HPLC)

assay

≥98% (HPLC)

assay

≥90% (HPLC)

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

solubility

DMSO: soluble 46 mg/mL

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 50 mg/mL

solubility

-

General description

Differentiation-inducing factor-3 (DIF-3) is a monochlorinated metabolite of differentiation-inducing factor-1 (DIF-1), that belongs to the differentiation-inducing factor (DIF) family.[1]

Application

DIF-3 has been used: as a glycogen synthase kinase-3β (GSK-3β) activator to determine if GSK-3β is required for the anti-inflammatory actions of VU0360172 (VuPAM) in murine microglia[2], as a phosphorylation inhibitor for GSK-3β to examine the links between activation of protein kinase B (PKB)/GSK-3β/Fyn axis and nuclear factor erythroid 2–related factor 2 (NRF2) retention[3], as a GSK3β activator to study its effects on the cyclooxygenase 2 (COX2) expression levels in human primary chondrocytes in response to visfatin, as a GSK3β activator to study its effects on the intracellular mechanics along with F-actin and β-tubulin fiber networks in human primary chondrocytes

Biochem/physiol Actions

DIF-3 Inhibits cell cycle by inducing G0/G1 arrest.
Differentiation-inducing factor-3 (DIF-3) prevents the proliferation of intestinal cancer cells in vitro and in vivo. It may serve as a novel anti-cancer agent.[1]

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
123K4614

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M Wang et al.
Developmental biology, 140(1), 182-188 (1990-07-01)
Stalk cell differentiation in Dictyostelium can be induced by the differentiation-inducing factor, DIF, or by conditions that decrease intracellular pH (pHi). We have investigated whether cytoplasmic acidification acts directly to induce expression of pDd56 and pDd63, two DIF-regulated genes, specifically
The search for morphogens in Dictyostelium.
L Bloom et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 9(6), 187-191 (1988-12-01)
Effects of Visfatin on Intracellular Mechanics and Catabolism in Human Primary Chondrocytes through Glycogen Synthase Kinase 3 beta Inactivation
Chang SF, et al.
International Journal of Molecular Sciences, 22(15), 8107-8107 (2021)
C R Thompson et al.
Developmental biology, 227(1), 56-64 (2000-11-15)
Cell fate in Dictyostelium development depends on intrinsic differences between cells, dating from their growth period, and on cell interactions occurring during development. We have sought for a mechanism linking these two influences on cell fate. First, we confirmed earlier
R R Kay et al.
Seminars in cell & developmental biology, 10(6), 577-585 (2000-03-09)
The DIFs are a family of secreted chlorinated molecules that control cell fate during development of Dictyostelium cells in culture and probably during normal development too. They induce stalk cell differentiation and suppress spore cell formation. The biosynthetic and inactivation
View All Related Papers

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Product Information Sheet - D0567

Product Information Sheet

Global Trade Item Number

SKUGTIN
D0567-1MG04061826744291

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