C9400

Calcium Ionophore A23187 hemimagnesium salt

• Synonym(s): A23187 hemimagnesium salt, Antibiotic A 23187 hemimagnesium salt, Calcimycin hemimagnesium salt, Calimycin hemimagnesium salt
• Empirical Formula (Hill Notation): C₂₉H₃₆Mg_0.5N₃O₆
• CAS Number: 72124-77-7
• Molecular Weight: 534.77
• UNSPSC Code: 12352202
• NACRES: NA.77
• PubChem Substance ID: 24893158
• MDL number: MFCD00151203
• Beilstein/REAXYS Number: 6765085

Properties

• sterility: non-sterile
• Quality Segment: 200
• form: powder
• antibiotic activity spectrum: Gram-positive bacteria, fungi
• mode of action: cell membrane | interferes
• storage temp.: 2-8°C
• SMILES string: CNc1ccc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@@H]([C@H](C)C[C@H]4C)[C@H](C)C(=O)c5ccc[nH]5)nc2c1C(=O)O[Mg]OC(=O)c6c(NC)ccc7oc(C[C@H]8O[C@@]9(CC[C@H]8C)O[C@@H]([C@H](C)C[C@H]9C)[C@H](C)C(=O)c%10ccc[nH]%10)nc67
• InChI: 1S/2C29H37N3O6.Mg/c2*1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35;/h2*6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35);/q;;+2/p-2/t2*15-,16-,17-,18-,22-,27+,29+;/m11./s1
• InChI key: XBWKBTZDBYFEMH-UIOMRPQBSA-L

Description

Application

Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase. Used to study effects of elevated intracellular calcium on mitochondrial function and intrinsic apoptosis.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H312 + H332,H315,H319,H335
• pcodes: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves