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Monoclonal Anti-Cyclin A antibody produced in mouse

Name: Monoclonal Anti-Cyclin A antibody produced in mouse
Brand: SIGMA
Price: 15725 CZK

clone CY-A1, ascites fluid

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Pack Size	SKU	Availability	Price
0.2 mL		Please contact Customer Service for Availability	CZK 18,500.00 CZK 15,725.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00243105

Conjugate:

unconjugated

Clone:

CY-A1, monoclonal

Application:

ARR, ICC, WB

Citations:

CZK 15,725.00

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Properties

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

CY-A1, monoclonal

mol wt

antigen 60 kDa

contains

15 mM sodium azide

species reactivity

mouse, human, monkey, bovine

technique(s)

immunocytochemistry: suitable, microarray: suitable, western blot: 1:1,000 using a mouse NIH 3T3 cell extract

isotype

IgG2a

UniProt accession no.

P20248

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CCNA2(890)
mouse ... Ccna2(12428)

Description

General description

Cyclin A is a nuclear protein during S phase and it binds both cdk2 and cdc2. The availability of monoclonal antibody reacting specifically with cyclin A enables the subcellular detection and localization of cyclin A and the measurement of relative differences in cyclin A levels as a function of cell cycle phase.

Immunogen

recombinant bovine cyclin A.

Application

Monoclonal Anti-Cyclin A antibody produced in mouse is suitable for:

immunocytochemistry
microarray
western blotting at a dilution of 1:1,000 using a mouse NIH 3T3 cell extract

Biochem/physiol Actions

The antibody recognizes an epitope present in amino acids 162-433 of bovine cyclin A. No cross-reactivity is detected with other cyclins (cyclin B, D, or E).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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1 of 1

This Item	C8218	C8831	WH0008900M2
Sigma-Aldrich C4710 Monoclonal Anti-Cyclin A antibody produced in mouse	Sigma-Aldrich C8218 Monoclonal Anti-Cdk4 antibody produced in mouse	$Anti-Cyclin B1 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich C8831 Anti-Cyclin B₁ antibody produced in rabbit	Sigma-Aldrich WH0008900M2 Monoclonal Anti-CCNA1 antibody produced in mouse
biological source mouse	biological source mouse	biological source rabbit	biological source mouse
Gene Information human ... CCNA2(890) mouse ... Ccna2(12428)	Gene Information human ... CDK4(1019) mouse ... Cdk4(12567) rat ... Cdk4(94201)	Gene Information human ... CCNB1(891) mouse ... Ccnb1(268697)	Gene Information human ... CCNA1(8900)
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form ascites fluid	antibody form ascites fluid	antibody form IgG fraction of antiserum	antibody form purified immunoglobulin
clone CY-A1, monoclonal	clone DCS-31, monoclonal	clone polyclonal	clone 4A11-5B5, monoclonal
species reactivity mouse, human, monkey, bovine	species reactivity rat, mouse, human	species reactivity human, mouse, hamster	species reactivity human

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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NOTCH1 mediates a switch between two distinct secretomes during senescence.

Matthew Hoare et al.

Nature cell biology, 18(9), 979-992 (2016-08-16)

Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse secretome, which provides complex functionality for senescent cells within the tissue microenvironment. We show that oncogene-induced senescence is accompanied by a dynamic fluctuation of NOTCH1 activity, which

Switch from p53 to MDM2 as differentiating human keratinocytes lose their proliferative potential and increase in cellular size.

J E Dazard et al.

Oncogene, 19(33), 3693-3705 (2000-08-19)

p53 transcription factor is mutated in most skin cell carcinomas and in more than 50% of all human malignancies. One of its transcriptional targets is MDM2, which in turn down-regulates p53. The role of the p53/MDM2 regulatory loop upon genotoxic

Transient association of MCM complex proteins with the nuclear matrix during initiation of mammalian DNA replication.

Emma L Hesketh et al.

Cell cycle (Georgetown, Tex.), 14(3), 333-341 (2015-02-07)

The minichromosome maintenance complex (MCM2-7) is the putative DNA helicase in eukaryotes, and essential for DNA replication. By applying serial extractions to mammalian cells synchronized by release from quiescence, we reveal dynamic changes to the sub-nuclear compartmentalization of MCM2 as

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Global Trade Item Number

SKU	GTIN
C4710-.2ML	04061837867774

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