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C199

CGS-15943

≥98% (HPLC), Adenosine receptor antagonist, solid

Synonym(s):

9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine

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Pack SizeSKUAvailabilityPrice
25 mg
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CZK 4,000.00

About This Item

Empirical Formula (Hill Notation):
C13H8ClN5O
CAS Number:
104615-18-1
Molecular Weight:
285.69
UNSPSC Code:
12352202
PubChem Substance ID:
24277704
NACRES:
NA.77
MDL number:
MFCD01529897
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100

CZK 4,000.00

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Product Name

CGS-15943, solid

assay

≥98% (HPLC)

Quality Level

100

form

solid

color

white

solubility

DMSO: >10 mg/mL, H2O: insoluble

storage temp.

room temp

SMILES string

Nc1nc2ccc(Cl)cc2c3nc(nn13)-c4ccco4

InChI

1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16)

InChI key

MSJODEOZODDVGW-UHFFFAOYSA-N

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This Item
S4568S6451Z0153
CGS-15943 solid

Sigma-Aldrich

C199

CGS-15943

SCH 58261 ≥98% (HPLC), solid

Sigma-Aldrich

S4568

SCH 58261

SCH-442416 ≥98% (HPLC)

Sigma-Aldrich

S6451

SCH-442416

ZM 241385 ≥98% (HPLC)

Sigma-Aldrich

Z0153

ZM 241385

form

solid

form

solid

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

solubility

DMSO: >10 mg/mL, H2O: insoluble

solubility

DMSO: soluble >10 mg/mL, H2O: insoluble

solubility

DMSO: ≥20 mg/mL

solubility

DMSO: >15 mg/mL

storage temp.

room temp

storage temp.

-

storage temp.

2-8°C

storage temp.

room temp

color

white

color

off-white

color

light tan to tan

color

white to tan

Application

CGS-15943 has been used as a non-selective adenosine receptor antagonist to study its effects on the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and hepatocellular carcinoma (HCC)[1]. It has also been used as a non-selective adenosine receptor antagonist to investigate the mechanism underlying adenosine inhibition on cholangiocarcinoma (CCA) cells.[2]

Biochem/physiol Actions

CGS-15943 is a potent and non-selective adenosine receptor antagonist. It exhibits anti-carcinogenic and anti-apoptotic activity.[1]

ppe

Eyeshields, Gloves, type N95 (US)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000364481
0000364481
0000216290
0000216290
0000209086

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J m Li et al.
The Journal of surgical research, 80(2), 357-364 (1999-01-08)
Adenosine is a potent vasodilator of vascular smooth muscle. Endothelium-derived nitric oxide (NO) elicits vasodilation. We have previously reported that adenosine stimulates the production of NO from porcine carotid arterial endothelial cells (PCAEC) via a receptor-mediated mechanism. This study was
E Ongini et al.
Naunyn-Schmiedeberg's archives of pharmacology, 359(1), 7-10 (1999-02-05)
Three structurally related non-xanthine compounds, CGS 15943, ZM 241385 and SCH 58261, are potent A2A adenosine receptor antagonists and have been used as tools in many pharmacological studies. We have now characterized their affinity and selectivity profile on human adenosine
M Williams et al.
The Journal of pharmacology and experimental therapeutics, 241(2), 415-420 (1987-05-01)
CGS 15943A, a triazoloquinazoline, is a potent and selective adenosine receptor antagonist as assessed by its effects on radioligand binding and adenosine-stimulated adenylate cyclase activity in guinea pig synaptoneurosomes. At the adenosine A-1 receptor labeled with [3H]cyclohexyladenosine, CGS 15943A had
A C Ngai et al.
American journal of physiology. Heart and circulatory physiology, 280(5), H2329-H2335 (2001-04-12)
The purpose of this study was to investigate the receptor subtypes that mediate the dilation of rat intracerebral arterioles elicited by adenosine. Penetrating arterioles were isolated from the rat brain, cannulated with the use of a micropipette system, and luminally
Lazaros C Foukas et al.
The Journal of biological chemistry, 277(40), 37124-37130 (2002-07-30)
We investigated the effects of methylxanthines on enzymatic activity of phosphoinositide 3-kinases (PI3Ks). We found that caffeine inhibits the in vitro lipid kinase of class I PI3Ks (IC(50) = 75 microm for p110 delta, 400 microm for p110 alpha and
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Global Trade Item Number

SKUGTIN
C199-25MG04061833474914

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