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C1617

C Reactive Protein human

recombinant, expressed in E. coli, liquid

Synonym(s):

CRP

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Size/SKUAvailabilityPrice
1 mg
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19 800,00 CZK

About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:

19 800,00 CZK


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recombinant

expressed in E. coli

Quality Segment

form

liquid

mol wt

23 kDa

bp

~100 °C

UniProt accession no.

storage temp.

2-8°C

Gene Information

human ... CRP(1401)

General description

C-reactive protein (CRP), a homopentameric acute-phase inflammatory protein, is produced mainly in liver hepatocytes. This highly conserved plasma protein is also produced by smooth muscle cells, macrophages, endothelial cells, lymphocytes, and adipocytes. It belongs to the pentraxin family.

Application

C Reactive Protein human has been used:
  • as a component in differentiation medium to study the effects of C-reactive protein (CRP) on the size of myotubes and myotube mixed protein synthesis (MPS)
  • to study the influence of serum CRP level from elderly on endothelial cell proliferation in human umbilical vein endothelial cells (HUVEC)
  • to study the roles and connections of nicotine, monocytic interleukin 6 (IL-6), α7 nicotinic acetylcholine receptor (α7-nAChR), and CRP in the development of coronary artery spasm (CAS)

Biochem/physiol Actions

C-reactive protein (CRP) plays a key role in the complement pathway, apoptosis, phagocytosis, nitric oxide (NO) release, and the production of interleukin-6 and tumor necrosis factor-α. It participates in the uptake of low-density lipoprotein in macrophages. CRP levels are elevated in people suffering from appendicitis, cholecystitis, pancreatitis, and meningitis. It plays a vital role in the pathophysiology of cardiovascular disease. Hence it is used as a marker of infection and cardiovascular events.
C-reactive protein (CRP) is a protein that could precipitate the C-polysaccharide of pneumococcal cell walls. CRP is widely used as a clinical marker of the state of inflammation, since its production by hepatocytes increases during the acute phase of the inflammatory response.

Analysis Note

A highly purified protein and made by a fermentation process using genetically modified E. coli.

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This Item
MSST0022C3527SAB5701145
description

recombinant, expressed in E. coli, liquid

description

recombinant, expressed in HEK 293 cells, MS Protein Standard

description

IgG fraction of antiserum, lyophilized powder

description

-

recombinant

expressed in E. coli

recombinant

expressed in HEK 293 cells

recombinant

-

recombinant

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

form

liquid

form

liquid

form

lyophilized powder

form

liquid

Gene Information

human ... CRP(1401)

Gene Information

human ... PTX3(5806)

Gene Information

human ... CRP(1401)

Gene Information

human ... CRP(1401)

mol wt

23 kDa

mol wt

-

mol wt

-

mol wt

-

UniProt accession no.

P02741

UniProt accession no.

P02741

UniProt accession no.

P02741

UniProt accession no.

P02741


Storage Class

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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Questions

1–2 of 2 Questions  
  1. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  2. How is the protein concentration of product C1617, human recombinant C-Reactive Protein, determined?

    1 answer
    1. The absorbance of the solution at 280 nm is read and the protein concentration calculated using an E(1%) of 17.

      Helpful?

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