C160

CGP-42112A

synthetic, ≥95%, Angiotensin II receptor antagonist, solid

• Synonym(s): N_α-Nicotinoyl-Tyr-(N_α-Cbz-Arg)-Lys-His-Pro-Ile
• Empirical Formula (Hill Notation): C₅₂H₆₉N₁₃O₁₁
• CAS Number: 127060-75-7
• Molecular Weight: 1052.18
• NACRES: NA.77
• PubChem Substance ID: 24892424
• UNSPSC Code: 12352200
• MDL number: MFCD00133611
• Beilstein/REAXYS Number: 8184948
• Assay: ≥95%
• Form: solid

Properties

• Product Name: CGP-42112A, ≥95%, synthetic, solid
• biological source: synthetic
• Quality Segment: 200
• assay: ≥95%
• form: solid
• color: white
• storage temp.: −20°C
• SMILES string: CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc3ccccc3)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)c5cccnc5)C(O)=O
• InChI: 1S/C52H69N13O11/c1-3-32(2)43(50(73)74)64-48(71)42-17-11-25-65(42)49(72)41(27-36-29-56-31-59-36)62-46(69)39(60-47(70)40(26-33-18-20-37(66)21-19-33)61-44(67)35-14-9-22-55-28-35)15-7-8-23-57-45(68)38(16-10-24-58-51(53)54)63-52(75)76-30-34-12-5-4-6-13-34/h4-6,9,12-14,18-22,28-29,31-32,38-43,66H,3,7-8,10-11,15-17,23-27,30H2,1-2H3,(H,56,59)(H,57,68)(H,60,70)(H,61,67)(H,62,69)(H,63,75)(H,64,71)(H,73,74)(H4,53,54,58)/t32-,38-,39-,40-,41-,42-,43-/m0/s1
• InChI key: UXGNARZDONUMMK-LRMQDCNJSA-N
• Gene Information: human ... AGTR2(186) ; rat ... AGTR2(11609)

Description

Application

CGP-42112A has been used:

• in the isolation of RNA from fibroblast-like synoviocytes from rheumatoid arthritis patients (RA-FLS)
• to study its effects on the ERK2 phosphorylation in the cardiomyoblast cell line
• as a stimulator of angiotensin II type 2 (AT2) receptor to study its effects on human regional hemodynamic responses mediated by AT2 receptors

Biochem/physiol Actions

CGP-42112A is a potent angiotensin II type 2 receptor (AT2R) agonist.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)