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5-Carboxamidotryptamine maleate salt

Name: 5-Carboxamidotryptamine maleate salt
Brand: SIGMA
Price: 6281.5 CZK

powder, ≥98% (HPLC)

Synonym(s):

5-CT, AH-21467

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Pack Size	SKU	Availability	Price
5 mg		Please contact Customer Service for Availability	CZK 7,390.00 CZK 6,281.50
25 mg		Please contact Customer Service for Availability	CZK 27,500.00

About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₃N₃O · C₄H₄O₄

CAS Number:

74885-72-6

Molecular Weight:

319.31

NACRES:

NA.77

PubChem Substance ID:

24278086

UNSPSC Code:

12352116

MDL number:

MFCD00069224

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

H₂O: 10 mg/mL

storage temp.

−20°C

SMILES string

OC(=O)\C=C/C(O)=O.NCCc1c[nH]c2ccc(cc12)C(N)=O

InChI

1S/C11H13N3O.C4H4O4/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10;5-3(6)1-2-4(7)8/h1-2,5-6,14H,3-4,12H2,(H2,13,15);1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

PZQZSWAOVAMBQM-BTJKTKAUSA-N

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR2A(3356), HTR2C(3358), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)
rat ... Htr7(65032)

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Show Differences

1 of 1

This Item	M110	SML0640	SML1087
Sigma-Aldrich C117 5-Carboxamidotryptamine maleate salt	Sigma-Aldrich M110 α-Methylserotonin maleate salt	Sigma-Aldrich SML0640 2-Methylserotonin maleate	Sigma-Aldrich SML1087 Sumanirole maleate
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥95% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C
solubility H₂O: 10 mg/mL	solubility H₂O: >3 mg/mL, clear (warmed)	solubility H₂O: 5 mg/mL, clear	solubility H₂O: 10 mg/mL, clear
color white to off-white	color white to dark brown	color white to brown	color white to beige

Biochem/physiol Actions

Agonist at 5-HT_1A, 5-HT_1B, 5-HT_1D, 5-HT₅ and 5-HT₇ serotonin receptors.

comparable product

Product No.

Description

Pricing

L3169

LP 12 hydrochloride hydrate, ≥98% (HPLC), solid

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Synthesis and structure-activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT₂B and 5-HT₇ receptor antagonists. Part 2.

Ayako Moritomo et al.

Bioorganic & medicinal chemistry, 22(15), 4323-4337 (2014-06-12)

We previously reported that the novel dual 5-HT₂B and 5-HT7 receptor antagonist N-(9-hydroxy-9H-fluorene-2-carbonyl)guanidine (4) exerted a suppressing effect on 5-HT-induced dural protein extravasation in guinea pigs. To develop a synthetic strategy, we performed docking studies of lead compound 4 bound

Characterization of the human homozygous R182W POLG2 mutation in mitochondrial DNA depletion syndrome.

Kirsten E Hoff et al.

PloS one, 13(8), e0203198-e0203198 (2018-08-30)

Mutations in mitochondrial DNA (mtDNA) have been linked to a variety of metabolic, neurological and muscular diseases which can present at any time throughout life. MtDNA is replicated by DNA polymerase gamma (Pol γ), twinkle helicase and mitochondrial single-stranded binding

5-Hydroxytryptamine(7) receptor activation decreases slow afterhyperpolarization amplitude in CA3 hippocampal pyramidal cells.

W L Bacon et al.

The Journal of pharmacology and experimental therapeutics, 294(2), 672-679 (2000-07-20)

The 5-hydroxytryptamine(7) (5-HT(7)) receptor was originally defined by molecular biology techniques. The 5-HT(7) receptor protein and mRNA are found in brain areas, such as the CA3 subfield of the hippocampus, that are involved in various neuropsychiatric disease states. No functional

Preassociation between the 5-HT7 serotonin receptor and G protein Gs: molecular determinants and association with low potency activation of adenylyl cyclase.

Andrea Hembre Ulsund et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(3), 3870-3886 (2018-12-07)

According to early models of GPCR signaling, G proteins only interact with activated receptors. However, some GPCRs were shown to assemble with G proteins before receptor activation, in accordance with more recent models. Previously, we found that the 5-HT7 receptor

Modulation of serotonin and noradrenaline in the BLA by pindolol reduces long-term ethanol intake.

Omkar L Patkar et al.

Addiction biology, 24(4), 652-663 (2018-07-20)

Repeated cycles of binge-like alcohol consumption and abstinence change the activity of several neurotransmitter systems. Some of these changes are consolidated following prolonged alcohol use and are thought to play an important role in the development of dependence. We have

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Global Trade Item Number

SKU	GTIN
C117-25MG	04061832081342
C117-5MG	04061832081359

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