C0739
Anti-phospho-Cortactin (pTyr421) antibody produced in rabbit
affinity isolated antibody, buffered aqueous glycerol solution
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 1 vial | Please contact Customer Service for Availability | CZK 19,500.00 |
About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ICC, WB
Citations:
12
CZK 19,500.00
Please contact Customer Service for Availability
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
mol wt
antigen 80-85 kDa
species reactivity
mouse
technique(s)
immunocytochemistry: suitable, western blot: 1:1,000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr421)
Gene Information
mouse ... Cttn(13043)
General description
Cortactin is encoded by the CTTN gene on chromosome 11 in humans. It is a cytoskeleton protein that facilitates assembly of cortical actin. It is expressed in most adherent cells and is a prominent substrate of protein-tyrosine kinase Src.
Immunogen
synthetic phosphopeptide derived from the region of mouse cortactin that is phosphorylated on tyrosine 421.
Application
Anti-phospho-Cortactin (pTyr421) antibody produced in rabbit is suitable for immunocytochemistry and western blotting at a working dilution of 1:1,000
Biochem/physiol Actions
Cortactin is activated by phosphorylation of tyrosine kinases or serine/threonine kinases. It plays an important role in promoting lamellipodia formation, invadopodia formation, cell migration, and endocytosis. Cortactin regulates the interactions between components of adherens-type junctions and helps in organizing the cytoskeleton, cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. It acts as a regulator in invasion and migration of tumor cells. The overexpression of cortactin causes osteosarcoma carcinogenesis and along with FAK increases the risk of oral premalignant lesions.
Physical form
Solution in Dulbecco′s PBS, pH 7.3, 1mg/mL BSA, 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
1 of 1
This Item | |||
|---|---|---|---|
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| biological source rabbit | biological source rabbit | biological source rabbit | biological source rabbit |
| antibody form affinity isolated antibody | antibody form affinity isolated antibody | antibody form IgG fraction of antiserum | antibody form IgG fraction of antiserum |
| species reactivity mouse | species reactivity human, rat, mouse | species reactivity rat, human, mouse, chicken | species reactivity human, mouse, rat, chicken |
| shipped in wet ice | shipped in wet ice | shipped in dry ice | shipped in dry ice |
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Maxwell D Weidmann et al.
Scientific reports, 6, 36142-36142 (2016-11-09)
Invadopodia, actin-based protrusions of invasive carcinoma cells that focally activate extracellular matrix-degrading proteases, are essential for the migration and intravasation of tumor cells during dissemination from the primary tumor. We have previously shown that cortactin phosphorylation at tyrosine residues, in
Cortactin (CTTN) overexpression in osteosarcoma correlates with advanced stage and reduced survival.
Cecilia Folio et al.
Cancer biomarkers : section A of Disease markers, 10(1), 35-41 (2012-02-03)
The cortactin (CTTN) gene has been found, by transcriptomic profiling, to be overexpressed in pediatric osteosarcoma. The location of CTTN at 11q13 and the role of cortactin in cytoskeleton restructuring make CTTN of interest as a potential biomarker for osteosarcoma.
Aviv Bergman et al.
Cell adhesion & migration, 8(3), 273-279 (2014-04-10)
Invadopodia are dynamic protrusions in motile tumor cells whose function is to degrade extracellular matrix so that cells can enter into new environments. Invadopodia are specifically identified by microscopy as proteolytic invasive protrusions containing TKS5 and cortactin. The increasing complexity
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C0739-1VL | 04061826590393 |