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Carmustine

Name: Carmustine
Brand: SIGMA
Price: 2710 CZK

≥98% (TLC), oily liquid to amorphous solid, DNA alkylating agent

Synonym(s):

1,3-Bis(2-chloroethyl)-1-nitrosourea, BCNU

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Size/SKU	Availability	Price
25 mg	Please contact Customer Service for Availability	2 710,00 CZK
100 mg	Please contact Customer Service for Availability	8 140,00 CZK

About This Item

Empirical Formula (Hill Notation):

C₅H₉Cl₂N₃O₂

CAS Number:

154-93-8

Molecular Weight:

214.05

NACRES:

NA.77

PubChem Substance ID:

24278289

UNSPSC Code:

12352200

EC Number:

205-838-2

MDL number:

MFCD00057706

Assay:

≥98%

Form:

(Oily liquid to amorphous solid)

2 710,00 CZK

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Properties

Product Name

Carmustine, ≥98%

Quality Segment

200

assay

≥98%

form

(Oily liquid to amorphous solid)

mp

30 °C (lit.)

solubility

ethanol: 19.60-20.40 mg/mL, clear, pale yellow to yellow

originator

Bristol-Myers Squibb

storage temp.

−20°C

SMILES string

ClCCNC(=O)N(CCCl)N=O

InChI

1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11)

InChI key

DLGOEMSEDOSKAD-UHFFFAOYSA-N

Gene Information

human ... GSR(2936)

Description

General description

Carmustine is a mustard gas related β-chloro-nitrosourea compound, which is used in chemotherapy. It inhibits DNA replication and DNA transcription.

Application

Carmustine has been used to select transduced cells expressing MGMTP140K, a foamy virus vector. It has also been used in fluorescence-activated cell sorting (FACS) assay, to test the response of cell lines to carmustine.

Biochem/physiol Actions

Carmustine is a DNA alkylating agent causing DNA interstrand crosslinks. Effective against glioma and other solid tumors.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item	Y0002128	1096724	573110
Sigma-Aldrich C0400 Carmustine	Y0002128 Carmustine	USP 1096724 Carmustine	Sigma-Aldrich 573110 STAT5 Inhibitor III, Pimozide
description ≥98%	description European Pharmacopoeia (EP) Reference Standard	description United States Pharmacopeia (USP) Reference Standard	description The STAT5 Inhibitor III, Pimozide, also referenced under CAS 2062-78-4, controls the biological activity of STAT5. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
assay ≥98%	assay -	assay -	assay ≥98% (HPLC)
form (Oily liquid to amorphous solid)	form (Oily liquid to amorphous solid)	form (Oily liquid to amorphous solid)	form solid
Quality Level 200	Quality Level -	Quality Level -	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility ethanol: 19.60-20.40 mg/mL, clear, pale yellow to yellow	solubility -	solubility -	solubility DMSO: 50 mg/mL
originator Bristol-Myers Squibb	originator -	originator -	originator -

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300,H350,H360

pcodes

P201 - P301 + P310 + P330

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Repr. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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