B9934
BTA-1
≥98% (HPLC), solid
Synonym(s):
2-(4´-Methylaminophenyl)benzothiazole
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 mg | Please contact Customer Service for Availability | CZK 2,880.00 | |
| 25 mg | Please contact Customer Service for Availability | CZK 11,000.00 |
About This Item
Empirical Formula (Hill Notation):
C14H12N2S
CAS Number:
Molecular Weight:
240.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Biochem/physiol Actions
BTA-1 is a fluorescent thioflavin-T derivative with 50-fold higher affinity for β-amyloid aggregates.
BTA-1 is a probe for β-amyloid aggregates; fluorescent thioflavin-T derivative; exhibits high affinity for amyloid deposits; displays 50-fold higher affinity than thioflavin-T; selectively stains cerebral plaques and cerebrovascular amyloid deposits in the brains of PS1/APP transgenic mice, as well as Aβ fibrils in postmortem brain tissue obtained from AD patients; crosses the blood brain barrier.
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This Item | |||
|---|---|---|---|
| form solid | form solid | form solid | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: soluble ~10 mg/mL | solubility DMSO: >10 mg/mL | solubility DMSO: >10 mg/mL, H2O: insoluble | solubility DMSO: 10 mg/mL, clear |
| color yellow | color white to off-white | color white to off-white | color white to beige |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Related Content
Chester A Mathis et al.
Bioorganic & medicinal chemistry letters, 12(3), 295-298 (2002-01-30)
The synthesis of a new lipophilic thioflavin-T analogue (2-[4' -(methylamino)phenyl]benzothiazole, 6) with high affinity for amyloid is reported. Intravenous injection of [(11)C]-labeled 6 in control mice resulted in high brain uptake. Amyloid deposits were imaged with multiphoton microscopy in the
Ruiqing Ni et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 59(6), 960-966 (2018-02-09)
Fibrillary tau aggregates in Alzheimer disease and allied neurodegenerative disorders have been visualized in vivo by PET, whereas mechanistic links between PET-detectable tau deposits and neurotoxicity remain elusive. Here, we took advantage of transgenic mouse models of tauopathies to evaluate
Alex C Kwan et al.
Optics express, 17(5), 3679-3689 (2009-03-05)
Intrinsic optical emissions, such as autofluorescence and second harmonic generation (SHG), are potentially useful for functional fluorescence imaging and biomedical disease diagnosis for neurodegenerative diseases such as Alzheimer's disease (AD). Here, using multiphoton and SHG microscopy, we identified sources of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| B9934-25MG | 04061832977126 |
| B9934-5MG | 04061832977133 |