B4313

(E/Z)-BCI hydrochloride

Name: (E/Z)-BCI hydrochloride
Brand: SIGMA
Price: 5312.5 CZK

≥98% (HPLC)

Synonym(s):

(E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one; 3-(cyclohexylamino)-2,3-dihydro-2-(phenylmethylene)-1Hinden-1-one; 2-benzylidene-3-(cyclohexylamino)-1-Indanone hydrochloride, NSC 150117 hydrochloride

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5 MG

CZK 5,312.50

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CZK 20,400.00

CZK 5,312.50

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₃NO · HCl

CAS Number:

95130-23-7

Molecular Weight:

353.89

NACRES:

NA.77

PubChem Substance ID:

329773232

UNSPSC Code:

51111800

MDL number:

MFCD16875416

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

Key Documents

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assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

Cl.O=C1C(=Cc2ccccc2)C(NC3CCCCC3)c4ccccc14

InChI

1S/C22H23NO.ClH/c24-22-19-14-8-7-13-18(19)21(23-17-11-5-2-6-12-17)20(22)15-16-9-3-1-4-10-16;/h1,3-4,7-10,13-15,17,21,23H,2,5-6,11-12H2;1H

InChI key

JPATUDRDKCLPTI-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Inhibitors

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Show Differences

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This Item	SML1940	D6821	SML3185
B4313 (E/Z)-BCI hydrochloride	Sigma-Aldrich SML1940 ADDA 5 hydrochloride	Sigma-Aldrich D6821 Donepezil hydrochloride	Sigma-Aldrich SML3185 CGP 48664 dihydrochloride
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. room temp	storage temp. −20°C
storage condition desiccated	storage condition desiccated	storage condition desiccated	storage condition desiccated
solubility DMSO: 10 mg/mL, clear	solubility DMSO: 2 mg/mL, clear	solubility DMSO: ≥20 mg/mL, H₂O: ≥20 mg/mL	solubility DMSO: 2 mg/mL, clear (warmed)

Application

(E/Z)-BCI hydrochloride has been used:

to evaluate the role of the Duox-H₂O₂-Dusp6 derepression signaling pathway in heart regeneration[1]
as an MKP-1 inhibitor to investigate the role of MKP-1 on bexarotent-induced effects
as a dual specificity phosphatase 6 (DUSP6) inhibitor to study its effects on the proliferation of SKOV3 cells[2]

Biochem/physiol Actions

(E/Z)-BCI Hydrochloride is an inhibitor of dual-specificity phosphatase 6 (Dusp6) and Dusp1; hyperactivates FGF signaling.

BCI is an allosteric inhibitor of Dusp6 that acts within the phosphatase domain to prevent the catalytic stimulation of phosphatase activity induced by ERK2 substrate binding. BCI also hyperactivates FGF signaling, since Dusp6 functions as a feedback regulator of FGF signaling.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Bexarotent Attenuated Chronic Constriction Injury-Induced Spinal Neuroinflammation and Neuropathic Pain by Targeting Mitogen-Activated Protein Kinase Phosphatase-1.

Yulong Gui et al.

The journal of pain, 21(11-12), 1149-1159 (2019-01-21)

It is widely accepted that neuroinflammation in the spinal cord contributes to the development of central sensitization in neuropathic pain. Mitogen-activated protein kinase (MAPK) activation plays a vital role in the development of neuroinflammation in the spinal cord. In this

Bexarotent attenuated CCI-induced spinal neuroinflammation and neuropathic pain by targeting MKP-1

Gui Y, et al.

The Journal of Pain : Official Journal of the American Pain Society (2019)

HE4 Compromises Cytotoxic Mononuclear Cells via Inducing Dual Specificity Phosphatase 6

James NE, et al.

Frontiers in Pharmacology, 10, 216-216 (2019)

The kynurenine derivative 3-HAA sensitizes hepatocellular carcinoma to sorafenib by upregulating phosphatases.

Guifang Gan et al.

Theranostics, 11(12), 6006-6018 (2021-04-27)

Objectives: Sorafenib is the only FDA-approved first-line target drug for HCC patients. However, sorafenib merely confers 3-5 months of survival benefit with less than 30% of HCC patients sensitive to sorafenib therapy. Thus, it's necessary to develop a sensitizer for

Human Epididymis Secretory Protein 4 (HE4) Compromises Cytotoxic Mononuclear Cells via Inducing Dual Specificity Phosphatase 6.

Nicole E James et al.

Frontiers in pharmacology, 10, 216-216 (2019-04-04)

While selective overexpression of serum clinical biomarker Human epididymis secretory protein 4 (HE4) is indicative of ovarian cancer tumorigenesis, much is still known about the mechanistic role of the HE4 gene or gene product. Here, we examine the role of

View All Related Papers

Global Trade Item Number

SKU	GTIN
B4313-5MG	04061833217535
B4313-25MG	04061833217528

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(E/Z)-BCI hydrochloride