B2809

Bactenecin

≥95% (HPLC)

• Empirical Formula (Hill Notation): C₆₃H₁₁₈N₂₄O₁₃S₂
• Molecular Weight: 1483.89
• NACRES: NA.85
• PubChem Substance ID: 329773208
• UNSPSC Code: 51102829
• MDL number: MFCD00236810

Properties

• Quality Segment: 200
• assay: ≥95% (HPLC)
• form: powder
• solubility: 1 mg/mL (in 1% TFA in H20)
• antibiotic activity spectrum: Gram-negative bacteria
• mode of action: cell membrane | interferes
• storage temp.: −20°C
• SMILES string: CC[C@H](C)[C@@H]1NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)C(C)C)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCNC(N)=N
• InChI: 1S/C63H118N24O13S2/c1-13-34(11)46-57(97)78-38(21-17-25-75-62(69)70)49(89)83-43(31(5)6)54(94)82-42(53(93)79-39(59(99)100)22-18-26-76-63(71)72)29-102-101-28-41(81-51(91)40(27-30(3)4)80-48(88)36(64)19-15-23-73-60(65)66)52(92)77-37(20-16-24-74-61(67)68)50(90)86-47(35(12)14-2)58(98)85-44(32(7)8)55(95)84-45(33(9)10)56(96)87-46/h30-47H,13-29,64H2,1-12H3,(H,77,92)(H,78,97)(H,79,93)(H,80,88)(H,81,91)(H,82,94)(H,83,89)(H,84,95)(H,85,98)(H,86,90)(H,87,96)(H,99,100)(H4,65,66,73)(H4,67,68,74)(H4,69,70,75)(H4,71,72,76)/t34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1
• InChI key: RHISNKCGUDDGEG-CJMCYECYSA-N

Description

General description

Chemical structure: peptide

Application

Bactenecin′s activity has been studied as a cyclic molecule as well as in a linear form.[1] It was used to study the functional role of Trk1p in the mechanism of other antifungal peptides.[2] It has been used to study chemokine and cytokine production, alteration of gene expression in host cells, and inhibition of proinflammatory responses of host cells to bacterial components.[3]

Biochem/physiol Actions

Bactenecin is a 12-amino acid cationic antimicrobial peptide from bovine neutrophils. It strongly binds to LPS and perturbs the structure, fluidity and permeability of the inner membrane. This results in the leakage of cytosol and subsequent death of the bacteria.[4]

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Peptide antibiotic, originally isolated from bovine neutrophil granules

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)