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Merck

B162

B-HT 920 dihydrochloride

solid, ≥98% (HPLC)

Synonym(s):

5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepine-2-amine dihydrochloride, Talipexole

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About This Item

Empirical Formula (Hill Notation):
C10H15N3S · 2HCl
CAS Number:
36085-73-1
Molecular Weight:
282.23
UNSPSC Code:
12352202
PubChem Substance ID:
24891601
MDL number:
MFCD00274573

Key Documents

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Product Name

B-HT 920 dihydrochloride, solid, ≥98% (HPLC)

InChI

1S/C10H15N3S.2ClH/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8;;/h2H,1,3-7H2,(H2,11,12);2*1H

SMILES string

Cl.Cl.Nc1nc2CCN(CCc2s1)CC=C

InChI key

DPQAXNSOFFYKDS-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

H2O: >20 mg/mL

Gene Information

rat ... Drd2(24318)

Biochem/physiol Actions

α2-adrenoceptor agonist; D2 dopamine receptor agonist.

Features and Benefits

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
028K4703
023K4700
014K4702

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Yoshitoki Takagawa et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 25(2), 197-202 (2002-06-06)
To investigate the vascular endothelial dysfunction in the insulin resistance syndrome, muscarinic and alpha2-adrenergic mediated relaxations were studied in the fructose-fed rat. Male Sprague-Dawley rats were fed either fructose-rich chow (FFR, n=14) or normal chow (CNT, n=13) for 8 weeks.
Beatriz Civantos et al.
European journal of pharmacology, 489(1-2), 101-110 (2004-04-06)
It has been suggested that the combination of dietary Ca and Ca2+ channel antagonists could have a synergic antihypertensive effect. In this study, 3-week-old male spontaneously hypertensive rats (SHR) were randomized into four groups of animals. Two of these groups
Minori Enomoto et al.
Movement disorders : official journal of the Movement Disorder Society, 23(6), 811-816 (2007-12-13)
This study was done to identify the clinical characteristics of uremic restless legs syndrome (RLS). Consecutive uremic RLS patients (n = 15) and idiopathic RLS patients (iRLS; n = 20) were evaluated. The groups were compared with respect to their
M R Corboz et al.
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Nasal congestion, one of the major disease features of rhinitis, is induced by the filling of venous sinusoids causing mucosal engorgement with resultant obstruction of nasal airflow. The only available drugs that directly target the underlying vascular features driving nasal
M R Corboz et al.
Pulmonary pharmacology & therapeutics, 21(3), 449-454 (2007-09-18)
The vascular bed in nasal mucosa of different species, including human, is highly vascularized and an extensive sinusoidal network of large capacitance vessels is present deep within the submucosa. When this network of venous sinusoids is engorged with blood, the
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