B1436

BAX Inhibiting Peptide V5

≥97% (HPLC), lyophilized powder

• Synonym(s): BIP-V5
• Empirical Formula (Hill Notation): C₂₇H₅₀N₆O₆S
• CAS Number: 579492-81-2
• Molecular Weight: 586.79
• UNSPSC Code: 12352200
• NACRES: NA.32
• MDL number: MFCD04974826

Properties

• Quality Segment: 200
• assay: ≥97% (HPLC)
• form: lyophilized powder
• storage temp.: −20°C
• SMILES string: S(CC[C@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)O)C
• InChI: 1S/C27H50N6O6S/c1-16(2)15-20(24(35)31-19(27(38)39)9-6-7-12-28)32-23(34)18(11-14-40-5)30-25(36)21-10-8-13-33(21)26(37)22(29)17(3)4/h16-22H,6-15,28-29H2,1-5H3,(H,30,36)(H,31,35)(H,32,34)(H,38,39)/t18-,19-,20-,21-,22-/m0/s1
• InChI key: NHMUTADCTDDWPV-YFNVTMOMSA-N

Description

Biochem/physiol Actions

Bax-mediated apoptosis inhibitor; membrane permeable pentapeptide based on the Ku70-Bax inhibiting domain.

BAX Inhibiting Peptide V5 protects Bax against conformational changes and it also prevents mitochondrial translocation. In vitro analysis prove that peptide V5 prevents apoptosis, mediated by a number of agents including staurosporine, ultraviolet and anti-cancer drug.

Other Notes

Lyophilized from 0.1% TFA in H2O

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)