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Merck

B0385

Beclomethasone

≥99%, anti-inflammatory agent, powder

Synonym(s):

9α-Chloro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Chloro-16β-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione

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100 MG

CZK 6,380.00

250 MG

CZK 13,900.00

1 G

CZK 38,000.00

CZK 6,380.00

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About This Item

Empirical Formula (Hill Notation):
C22H29ClO5
CAS Number:
4419-39-0
Molecular Weight:
408.92
NACRES:
NA.77
PubChem Substance ID:
24278253
UNSPSC Code:
12352200
EC Number:
224-585-9
MDL number:
MFCD00135614
Assay:
≥99%
Form:
powder
Quality level:
100

Key Documents

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Product Name

Beclomethasone, ≥99%

Quality Level

100

assay

≥99%

form

powder

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

[H][C@]12C[C@@H](C)[C@@](O)(C(=O)CO)[C@]1(C)C[C@@H](O)[C@@]3(Cl)[C@]2([H])CCC4=CC(=O)C=C[C@@]34C

InChI

1S/C22H29ClO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12?,15?,16?,17?,19?,20?,21-,22?/m0/s1

InChI key

NBMKJKDGKREAPL-WOOYFSPWSA-N

Gene Information

human ... CYP1A2(1544)

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1 of 4

This Item
B0515B7005D1756
Beclomethasone ≥99%

Sigma-Aldrich

B0385

Beclomethasone

Betamethasone 17-valerate

Sigma-Aldrich

B0515

Betamethasone 17-valerate

Betamethasone ≥98%

Sigma-Aldrich

B7005

Betamethasone

Dexamethasone ≥98% (HPLC), powder

D1756

Dexamethasone

form

powder

form

powder

form

powder

form

powder

assay

≥99%

assay

-

assay

≥98%

assay

≥98% (HPLC)

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

room temp

storage temp.

2-8°C

originator

GlaxoSmithKline

originator

Schering Plough

originator

-

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

Gene Information

human ... CYP1A2(1544)

Gene Information

-

Gene Information

human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

Gene Information

human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

Application

Beclomethasone has been used in MS−MS (mass spectrometry) methods for the analysis of β-agonists, corticosteroids, chloramphenicol and penicillins. It has also been used to find the differential response of glucocorticoids in larval regeneration model.

Biochem/physiol Actions

Beclomethasone is an anti-inflammatory glucocorticoid.
It helps to decrease airway hyperresponsiveness. It also helps to regulate symptoms of asthma.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX9731
MKCW1971
MKCW2001
MKCV4289
MKCV0784

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A comparison of beclomethasone, salmeterol, and placebo in children with asthma
Simons, FER, et al.
The New England Journal of Medicine, 337(23), 1659-1665 (1997)
Hong Ping Zhang et al.
Allergy and asthma proceedings, 35(4), 278-287 (2014-07-06)
It has proven efficacy in reducing asthma exacerbations, but the effect size of montelukast (a leukotriene receptor antagonist) for varied severity of asthma exacerbations is not systematically assessed. This study was designed to systematically explore the evidence for montelukast, as
Antonia Chatzopoulou et al.
Molecular and cellular endocrinology, 447, 61-70 (2017-03-01)
In humans, two splice variants of the glucocorticoid receptor (GR) exist: the canonical α-isoform, and the β-isoform, which has been shown to have a dominant-negative effect on hGRα. Previously, we have established the occurrence of a GR β-isoform in zebrafish
Hanna Valo et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 50(1), 69-77 (2013-03-19)
Highly porous nanocellulose aerogels prepared by freeze-drying from various nanofibrillar cellulose (NFC) hydrogels are introduced as nanoparticle reservoirs for oral drug delivery systems. Here we show that beclomethasone dipropionate (BDP) nanoparticles coated with amphiphilic hydrophobin proteins can be well integrated
Alternate glucocorticoid receptor ligand binding structures influence outcomes in an in vivo tissue regeneration model
Sengupta S, et al.
Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP, 156(2), 121-129 (2012)
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Global Trade Item Number

SKUGTIN
B0385-1G04061833419755
B0385-100MG04061832630984
B0385-250MG04061833419762

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