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Merck

B012

6-Fluoronorepinephrine hydrochloride

solid

Synonym(s):

6-FNE

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About This Item

Empirical Formula (Hill Notation):
C8H10FNO3 · HCl
CAS Number:
70952-50-0
Molecular Weight:
223.63
UNSPSC Code:
12352200
PubChem Substance ID:
24277756
MDL number:
MFCD01529921

Key Documents

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Product Name

6-Fluoronorepinephrine hydrochloride, solid

InChI

1S/C8H10FNO3.ClH/c9-5-2-7(12)6(11)1-4(5)8(13)3-10;/h1-2,8,11-13H,3,10H2;1H

SMILES string

FC1=CC(O)=C(O)C=C1C(O)CN.[H]Cl

InChI key

QGDCLYPALFHCCD-UHFFFAOYSA-N

form

solid

color

off-white

solubility

H2O: soluble

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)
rat ... Adra1a(29412), Adra2a(25083), Adrb1(24925), Adrb2(24176)

Biochem/physiol Actions

α-adrenoceptor agonist.

Disclaimer

Photosensitive. Solutions slowly oxidize in light/oxygen in a manner comparable to norepinephrine hydrochloride.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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L M Stevens et al.
Developmental biology, 123(1), 179-190 (1987-09-01)
Previous studies suggest that the sympathetic innervation of the sweat glands in the rat is initially noradrenergic and during development undergoes a transition in neurotransmitter phenotype to become cholinergic. To characterize this system and its development further, we have examined
L Brasili et al.
European journal of pharmacology, 144(2), 141-146 (1987-12-01)
The effect of 6F-, 5F- and 2F-norepinephrine (6F-, 5F- and 2F-NE) in rat vas deferens, guinea-pig ileum and pithed rats was compared to that of norepinephrine (NE). The rank order of potency on postsynaptic alpha 1-adrenoreceptors, determined from the isometric
C C Chiueh et al.
The Journal of pharmacology and experimental therapeutics, 225(3), 529-533 (1983-06-01)
In the present study 6-fluoronorepinephrine (6F-NE) is shown to be formed from 6-fluorodopamine (6F-DA) in vivo. The beta-hydroxylated fluorocompound is taken up by and stored in the adrenergic nerve terminals and can be released during sympathetic nerve stimulation. In the
T Kahan et al.
European journal of pharmacology, 133(1), 9-20 (1987-01-06)
Pre- and postjunctional effects of the alpha 1-selective adrenoceptor antagonist prazosin and the alpha 1- and alpha 2-selective adrenoceptor agonists methoxamine and 6-fluoronoradrenaline, respectively, were studied in skeletal muscle in situ. Prazosin reduced the vasoconstriction and enhanced the overflow of
J P Chang et al.
Neuroendocrinology, 54(3), 202-210 (1991-09-01)
Static incubations of dispersed goldfish pituitary cells with 1-100 nM norepinephrine (NE) stimulated gonadotropin (GTH) release. Additions of the alpha-agonist phenylephrine, and the alpha 1-agonist 6-fluoronorepinephrine, but not the alpha 2-agonist clonidine, nor the beta-agonist isoproterenol, also enhanced GTH secretion.
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