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A9434

Sigma-Aldrich

Ammonium chloride

for molecular biology, suitable for cell culture, ≥99.5%

Synonym(s):

Salmiac

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500 G
CZK 3,170.00
1 KG
CZK 5,490.00

CZK 3,170.00

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500 G
CZK 3,170.00
1 KG
CZK 5,490.00

About This Item

Linear Formula:
NH4Cl
CAS Number:
12125-02-9
Molecular Weight:
53.49
Beilstein:
4371014
EC Number:
235-186-4
MDL number:
MFCD00011420
UNSPSC Code:
12352302
eCl@ss:
38050207
PubChem Substance ID:
24891452
NACRES:
NA.31
Assay:
≥99.5%
grade:
for molecular biology
form:
powder or crystals

CZK 3,170.00

Please contact Customer Service for Availability
Request a Bulk Order

grade

for molecular biology

Quality Level

200

vapor density

1.9 (vs air)

vapor pressure

1 mmHg ( 160.4 °C)

Assay

≥99.5%

form

powder or crystals

technique(s)

cell culture | mammalian: suitable

mp

340 °C (subl.) (lit.)

anion traces

phosphate (PO43-): ≤2 ppm
sulfate (SO42-): ≤20 ppm

cation traces

Fe: ≤2 ppm
heavy metals (as Pb): ≤5 ppm

foreign activity

DNase, RNase, protease, none detected

SMILES string

N.Cl

InChI

1S/ClH.H3N/h1H;1H3

InChI key

NLXLAEXVIDQMFP-UHFFFAOYSA-N

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Application

Ammonium chloride has been used:
  • as an inhibitor of endosome acidification in vero cells[1]
  • as an autophagy inhibitor in vascular smooth muscle cell (VSMC)[2]
  • in the depletion and lysis of erythrocytes in testis parenchyma homogenate[3]

Biochem/physiol Actions

Ammonium chloride is one of the three principal components of the nitrogen cycle.[4] Ammonium chloride administration promotes creatinine and urea clearance[5] andinduces metabolic acidosis in mice.[6] Excess of ammonium chloride inhibits Kreb′s pathway in brain and depletes ATP in astrocytes.[7] Ammonium chloride inhibits acidification in the endosome-lysosome system.[8] Ammonium chloride is a hemolysing agent used for the lysis of erythrocytes.[9]

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000409896
0000396487
0000362597
0000358483
0000346081

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Infectious bronchitis virus entry mainly depends on clathrin mediated endocytosis and requires classical endosomal/lysosomal system
Wang H, et al.
Virology, 528, 118-136 (2019)
Aqueous ammonia and ammonium chloride hydrates: Principal infrared spectra
Max JJ and Chapados C
Journal of Molecular Structure, 1046, 124-135 (2013)
Effect of ammonium chloride and dietary phosphorus in the azotaemic rat. I. Renal function and biochemical changes
Jara A, et al.
Nephrology, Dialysis, and Transplantation, 19(8), 1986-1992 (2004)
Inhibition of endosome-lysosome system acidification enhances porcine circovirus 2 infection of porcine epithelial cells
Misinzo G, et al.
Journal of Virology, 82(3), 1128-1135 (2008)
Induction of metabolic acidosis with ammonium chloride (NH4Cl) in mice and rats-species differences and technical considerations
Nowik M, et al.
Cellular Physiology and Biochemistry, 26(6), 1059-1072 (2010)
View All Related Papers

Protocols

GenElute™ Mammalian Genomic DNA Miniprep Kit Protocol

The GenElute Mammalian Genomic DNA Purification Kit Protocol describes the isolation of pure, high molecular weight DNA from a variety of mammalian sources.

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. What are the dimensions of the bottles for the following SKUs: A9434-1KG (Ammonium chloride) and A7906-500G (Bovine Serum Albumin)?

    1 answer

    1. The dimensions for the bottles are as follows:

      A9434-1KG:
      • 1.5 L warm (WM), white (WHT), High Density Polyethylene (HDPE) bottle (BTL) with a red polypropylene cap.
      • Length: 125mm
      • Width: 125mm
      • Weight: 124g
      • Height: 220mm
      • Height with Cap: 224mm
      • Weight of the cap: 35g
      • Thread Diameter of cap: 80mm
      • Thread Type of cap: 80mm

      A7906-500G:
      • 2.5 L warm (WM), white (WHT), High Density Polyethylene (HDPE) bottle (BTL) with a red polypropylene cap.
      • Length: 127mm
      • Weight: 158g
      • Width: 127mm
      • Height: 280mm
      • Height with Cap: 284mm
      • Thread Diameter of cap: 80mm
      • Thread Type of cap: 80mm
      • Weight of cap: 39g

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