A7910
Apolipoprotein C-II from human plasma
≥95% (SDS-PAGE)
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| Size/SKU | Availability | Price |
|---|---|---|
50 μg | Please contact Customer Service for Availability | CZK 7,480.00 |
About This Item
biological source
human
Quality Segment
assay
≥95% (SDS-PAGE)
form
powder
mol wt
average mol wt 8.8 kDa
technique(s)
ligand binding assay: suitable
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... APOC2(344)
General description
Apolipoprotein C-II (APOC2/apoC-II), a small exchangeable apolipoprotein, is expressed in the liver and secreted into plasma. It is present on the triglyceride-rich lipoproteins (TRL), like chylomicrons (CM) and very-low-density lipoproteins (VLDL), and high-density lipoproteins (HDL), mainly during fasting. The intestine, macrophages, adipose tissue, brain, skin, lungs, retina, and retinal pigment epithelium are among the tissues that produce ApoC-II.[1]
Application
Apolipoprotein C-II activates lipoprotein lipase and has been used in a study to assess HDL proteome in hemodialysis patients. An excess of apolipoprotein C-II is associated with increased triglyceride-rich particles and alterations in HDL particle distribution.
Biochem/physiol Actions
Activates lipoprotein lipase
Apolipoprotein C2 (APOC2) serves as an activator of lipoprotein lipase. It is involved in the hydrolysis of triglycerides (TG) on TG-rich lipoproteins (TRL)[1] to release free fatty acids (FA).[2] Higher expression of APOC2 is observed in patient-derived glioblastoma stem cells, hypopharyngeal cancer, invasive ductal breast cancer, clear cell renal cell carcinoma, gastric cancer, centroblastic lymphoma, early-stage colorectal tumor, and skin squamous cell carcinoma.[2] ApoC-2 is considered as a new sensitive biomarker for diagnosing Takayasu arteritis (TAK).[3]
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This Item | |||
|---|---|---|---|
| biological source human | biological source - | biological source human | biological source human plasma |
| technique(s) ligand binding assay: suitable | technique(s) ELISA: suitable | technique(s) inhibition assay: suitable | technique(s) - |
| assay ≥95% (SDS-PAGE) | assay - | assay ≥95% (SDS-PAGE) | assay ≥95% (SDS-PAGE) |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| form powder | form - | form lyophilized powder | form buffered aqueous solution |
| Quality Level 200 | Quality Level - | Quality Level 200 | Quality Level 200 |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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