A7230
Alinidine
≥98% (HPLC), solid
Synonym(s):
N-(2,6-Dichlorophenyl)-4,5-dihydro-N-2-propenyl-1H-imidazol-2-amine, ST-567
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About This Item
Empirical Formula (Hill Notation):
C12H13Cl2N3
CAS Number:
Molecular Weight:
270.16
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
≥98% (HPLC)
form
solid
storage condition
under inert gas
color
off-white
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
Clc1cccc(Cl)c1N(CC=C)C2=NCCN2
Biochem/physiol Actions
Alinidine is an HCN Channel blocker of neuronal Ih, related cardiac If channels and ATP-sensitive Kir channels. It is an analog of clonidine; bradycardic and antiarrhythmic agent (sinus tachyarrhythmias). Alinidine affects physiological markers in conscious dogs. Alinidine in four intravenous (i.v.) injections of 0.5, 0.5, 1, and 2 mg/kg, decreased sinus rate (< or = 43%) and ventricular rate (< or = 44%), but increased atrial rate (< or = 31%). It lengthened CSRT (< or = 71%) at the two highest doses and increased AERP (< or = 33%) and decreased WP (< or = 33%) at all doses. Alinidine did not modify mean blood pressure at any dose in either group. These results indicate that alinidine exhibits electrophysiologic effects in conscious dogs that reflect the marked antiarrhythmic potential of this agent, apart from its assumed antiischemic properties.
Alinidine is an HCN channel blocker; Blocker of neuronal Ih, related cardiac If channels and ATP-sensitive Kir channels. Analog of clonidine; bradycardic and antiarrhythmic agent (sinus tachyarrhythmias).
Disclaimer
Air-sensitive
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Mirko Baruscotti et al.
Pharmacology & therapeutics, 107(1), 59-79 (2005-06-21)
First described over a quarter of a century ago, the cardiac pacemaker "funny" (I(f)) current has been extensively characterized since, and its role in cardiac pacemaking has been thoroughly demonstrated. A similar current, termed I(h), was later described in different
R E BoSmith et al.
British journal of pharmacology, 110(1), 343-349 (1993-09-01)
1. ZENECA ZD7288 (4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino) pyridinium chloride) is a sinoatrial node (SAN) modulating agent which produces a selective slowing of the heart rate. Its effects have been studied in single, freshly dissociated guinea-pig SAN cells, by standard patch clamp procedures. 2.
N J Lodge et al.
Naunyn-Schmiedeberg's archives of pharmacology, 354(4), 444-451 (1996-10-01)
The goal of the present study was to further characterize the effects of the novel cardioprotective agent BMS-180448 on potassium fluxes in cardiac and vascular smooth muscle. Exposure of voltage-clamped guinea pig ventricular myocytes to BMS-180448 (300 microM) produced an