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A6779

Sigma-Aldrich

Adenosine 5′-triphosphate, periodate oxidized sodium salt

≥97%

Synonym(s):

oATP, Adenosine 5′-triphosphate-2′,3′-dialdehyde

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About This Item

Empirical Formula (Hill Notation):
C10H14N5O13P3
CAS Number:
71997-40-5
Molecular Weight:
505.17
MDL number:
MFCD00056956
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
24891137
NACRES:
NA.51

biological source

bacterial (corynebacterium sp)

Assay

≥97%

form

powder

storage temp.

−20°C

SMILES string

[Na].Nc1ncnc2n(cnc12)[C@H](O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C=O)C=O

InChI

1S/C10H14N5O13P3.Na.H/c11-9-8-10(13-4-12-9)15(5-14-8)7(2-17)26-6(1-16)3-25-30(21,22)28-31(23,24)27-29(18,19)20;;/h1-2,4-7H,3H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;/t6-,7+;;/m0../s1

InChI key

IHQATUPGVKMGLT-AUCRBCQYSA-N

General description

Adenosine 5′-triphosphate 2′,3′ dialdehyde is a derivative of dialdehyde.

Application

Adenosine 5′-triphosphate, periodate oxidized sodium salt has been used:
  • as an antagonist of the purinergic receptor, P2 × 7 to inhibit P2 × 7 pathway
  • as a nonspecific agonist to assess the activity of P2×7-R by the mobilization of Ca2+
  • to evaluate the physiological significance of elevated intracellular ATP levels
  • increased P2rx7 expression for osteoclastogenesis in Flcn-deficient cells

Biochem/physiol Actions

Adenosine 5′-triphosphate 2′,3′ dialdehyde is considered as an inhibitor of P2 × 7 receptor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Frontiers in pharmacology, 8, 638-638 (2017-09-29)
William Foulsham et al.
Scientific reports, 9(1), 8617-8617 (2019-06-15)
Adenosine triphosphate (ATP) is released into the extracellular environment during transplantation, and acts via purinergic receptors to amplify the alloimmune response. Here, using a well-established murine model of allogeneic corneal transplantation, we investigated the immunomodulatory mechanisms of the purinergic receptor
Effect of nucleotide analogues on rotavirus transcription and replication
Pizarro JM, et al.
Virology, 184(2), 768-772 (1991)
Xuejing Cui et al.
Small (Weinheim an der Bergstrasse, Germany), 12(43), 5998-6011 (2016-09-21)
Exocytosis of single-walled carbon nanotubes (SWCNTs) determines therapeutic efficiency and toxicity of nanoproducts but its underlying mechanism remains elusive. In this study, it is found that the exocytosis mechanism of SWCNTs is mediated mainly through the activation of P2X7 receptor
Ursula Schenk et al.
Science signaling, 1(39), ra6-ra6 (2008-10-02)
T cell receptor (TCR) stimulation results in the influx of Ca(2+), which is buffered by mitochondria and promotes adenosine triphosphate (ATP) synthesis. We found that ATP released from activated T cells through pannexin-1 hemichannels activated purinergic P2X receptors (P2XRs) to
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