A5330

N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester

≥99% (TLC), powder

• Synonym(s): L-732,138
• Empirical Formula (Hill Notation): C₂₂H₁₈F₆N₂O₃
• CAS Number: 148451-96-1
• Molecular Weight: 472.38
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277690
• MDL number: MFCD00237267

Properties

• assay: ≥99% (TLC)
• form: powder
• mp: 147-148 °C (lit.)
• storage temp.: −20°C
• SMILES string: CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc3cc(cc(c3)C(F)(F)F)C(F)(F)F
• InChI: 1S/C22H18F6N2O3/c1-12(31)30-19(8-14-10-29-18-5-3-2-4-17(14)18)20(32)33-11-13-6-15(21(23,24)25)9-16(7-13)22(26,27)28/h2-7,9-10,19,29H,8,11H2,1H3,(H,30,31)/t19-/m0/s1
• InChI key: BYYQYXVAWXAYQC-IBGZPJMESA-N
• Gene Information: human ... TACR1(6869)

Description

Biochem/physiol Actions

Competitive substance P receptor antagonist.

Competitive substance P receptor antagonist. It is approximately 1000-fold more potent at cloned human NK-1 receptors than at cloned human NK-2 and NK-3 receptors; and approximately 200-fold more potent at human NK-1 receptors than at rat NK-1 receptors. The IC₅₀ for the human NK-1 receptor expressed in CHO cells is approximately 2 nM.

Safety Information

• Storage Class: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)