The solubility in DMSO is listed as 30-40 mg/mL. It may be soluble above that concentration, but it would need to be tested empirically by the end user.
A4888
Amphotericin B from Streptomyces sp.
~80% (HPLC), powder
Promotion Available
Synonym(s):
LNS-AmB, NSC 527017
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| Size/SKU | Availability | Price |
|---|---|---|
100 mg | Please contact Customer Service for Availability | 1 800,00 CZK |
250 mg | Please contact Customer Service for Availability | 3 920,00 CZK |
500 mg | Please contact Customer Service for Availability | 7 010,00 CZK |
1 g | Please contact Customer Service for Availability | 13 200,00 CZK |
5 g | Please contact Customer Service for Availability | 50 200,00 CZK 35 140,00 CZK |
100 g | Please contact Customer Service for Availability | 699 600,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C47H73NO17
CAS Number:
Molecular Weight:
924.08
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
EC Number:
215-742-2
Beilstein/REAXYS Number:
78342
MDL number:
biological source
Streptomyces sp.
Quality Segment
assay
~80% (HPLC)
form
powder
color
yellow to orange
solubility
DMF: 2-4 mg/mL, DMSO: 30-40 mg/mL, H2O: insoluble, water: insoluble
antibiotic activity spectrum
fungi, yeast
application(s)
advanced drug delivery
mode of action
cell membrane | interferes
storage temp.
2-8°C
SMILES string
C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@](O)(C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\2)C[C@H](O)[C@H]3C(O)=O)[C@@H](O)[C@@H](N)[C@@H]1O
InChI
1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
InChI key
APKFDSVGJQXUKY-INPOYWNPSA-N
General description
Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. and has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes.
Application
Amphotericin B is used to study the affects of the influx of calcium on antifungal activity, and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers . It is also commonly used in tissue culture as an antifungal supplement.
Amphotericin B from Streptomyces sp. has been used-
Amphotericin B from Streptomyces sp. has been used-
Biochem/physiol Actions
Amphotericin B binds to sterols, forming pores in the membrane, and causing small molecules to leak out. The product is most effective against fungi and yeast.
Mode of Action: Amphotericin B binds to sterols, forming pores in the membrane, and causing small molecules to leak out.
Antimicrobial spectrum: Includes fungi and yeast
Antimicrobial spectrum: Includes fungi and yeast
Features and Benefits
High quality antibiotic suitable for mulitple research applications
Preparation Note
Tightly closed. Dry. Keep in a well -ventilated place. Keep locked up or in an area accessible
Amphotericin B is insoluble in water at pH 6 to 7, but soluble in water at pH 2 or 11. It is soluble in DMSO (30-40 mg/mL) and in dimethylformamide (2-4 mg/mL). Aqueous solutions cannot be sterile filtered due to poor solubility.
Amphotericin B remains active for 3 days in culture at 37°C. At -20°C, and with protection from air and light, the product remains active for 5 years.
Amphotericin B remains active for 3 days in culture at 37°C. At -20°C, and with protection from air and light, the product remains active for 5 years.
Other Notes
For additional information on our range of Biochemicals, please complete this form.
Keep container tightly closed in a dry and well-ventilated place. Product is sensitive to light and moisture. Keep in a dry place.
1 of 1
This Item | |||
|---|---|---|---|
| description ~80% (HPLC), powder | description BioReagent, suitable for cell culture, ~80% (HPLC) | description powder, γ-irradiated, BioXtra, suitable for cell culture | description 250 μg/mL in deionized water, 0.1 μm filtered, BioReagent, suitable for cell culture |
| mode of action cell membrane | interferes | mode of action cell membrane | interferes | mode of action cell membrane | interferes | mode of action cell membrane | interferes |
| antibiotic activity spectrum yeast, fungi | antibiotic activity spectrum yeast, fungi | antibiotic activity spectrum fungi, yeast | antibiotic activity spectrum yeast, fungi |
| Quality Level 300 | Quality Level 300 | Quality Level 300 | Quality Level 200 |
| assay ~80% (HPLC) | assay ~80% (HPLC) | assay - | assay - |
| form powder | form solid | form powder | form liquid |
| application(s) advanced drug delivery | application(s) - | application(s) - | application(s) - |
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target_organs
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Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Storage Class
11 - Combustible Solids
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I would like to perform a MIC assay and any powder that is not completely dissolved may affect the accuracy and reproducibility of MIC results. May I know if this product can fully dissolved in DMSO?
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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