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A2169

3′-Azido-3′-deoxythymidine

≥98% (HPLC), powder, reverse transcriptase inhibitor

Synonym(s):

AZT, Azidothymidine, ZDV, Zidovudine

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Size/SKUAvailabilityPrice
25 mg
Please contact Customer Service for Availability
2 240,00 CZK
100 mg
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7 000,00 CZK
250 mg
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12 700,00 CZK
1 g
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41 100,00 CZK

About This Item

Empirical Formula (Hill Notation):
C10H13N5O4
CAS Number:
30516-87-1
Molecular Weight:
267.24
NACRES:
NA.77
PubChem Substance ID:
24278143
UNSPSC Code:
12352200
MDL number:
MFCD00006536
Beilstein/REAXYS Number:
3595791
Assay:
≥98% (HPLC)
Form:
powder

2 240,00 CZK

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Product Name

3′-Azido-3′-deoxythymidine, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

mp

113-115 °C (lit.)

solubility

H2O: 50 mg/mL

storage temp.

−20°C

SMILES string

CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

InChI key

HBOMLICNUCNMMY-XLPZGREQSA-N

Gene Information

human ... HIVE1(3095)
mouse ... Slc29a1(63959)

Application

3′-Azido-3′-deoxythymidine has been used as the reverse transcriptase inhibitor to inhibit the viral genome integration and as an antimicrobial agent to evaluate its anti-Salmonella activity.

Biochem/physiol Actions

Azidothymidine (AZT), a thymidine analogue, is a reverse transcriptase inhibitor against the HIV-1 virus. Azidothymidine has been shown to decrease CRISPR-mediated homology-directed repair (HDR) efficiency.
Reverse transcriptase inhibitor active against HIV-1 virus.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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This Item
1724500Z1900000BP895
3′-Azido-3′-deoxythymidine ≥98% (HPLC)

Sigma-Aldrich

A2169

3′-Azido-3′-deoxythymidine

Zidovudine United States Pharmacopeia (USP) Reference Standard

USP

1724500

Zidovudine

Zidovudine European Pharmacopoeia (EP) Reference Standard

Z1900000

Zidovudine

Zidovudine impurity standard British Pharmacopoeia (BP) Reference Standard

BP895

Zidovudine impurity standard

description

≥98% (HPLC)

description

United States Pharmacopeia (USP) Reference Standard

description

European Pharmacopoeia (EP) Reference Standard

description

British Pharmacopoeia (BP) Reference Standard

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

form

powder

form

-

form

-

form

solid

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: 50 mg/mL

solubility

-

solubility

-

solubility

-

Gene Information

human ... HIVE1(3095)
mouse ... Slc29a1(63959)

Gene Information

-

Gene Information

-

Gene Information

-

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Codes

H341,H351

Hazard Classifications

Carc. 2 - Muta. 2

Storage Class

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Questions

  1. For the use of this product in cell culture, what would be the best conditions for making stock solutions. Solvent, concentration, filtering, storage temp etc.?

    1 answer

    1. Unfortunately, this product has not been tested for cell culture applications. This compound is soluble at 50 mg/mL in water. For use in cell culture, the stock solution should be filter sterilized. Syringe filter product SLGVR33RS may be of interest. The pharmaceutical literature suggests that the stock solution is stable for 1 day at room temperature and 2 days if refrigerated.

      See the link below to a publication (page 3) regarding the stability of AZT in solution:
      https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/019910s041lbl.pdf

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