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Merck

A0885

Aurintricarboxylic acid ammonium salt

powder

Synonym(s):

ATA, Aluminon, Ammonium aurintricarboxylate

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25 G

CZK 2,400.00

CZK 2,400.00

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About This Item

Linear Formula:
C22H14O9 · 3NH3
CAS Number:
569-58-4
Molecular Weight:
473.43
EC Number:
209-319-1
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
24890465
MDL number:
MFCD00040925
Colour Index Number:
43810
Beilstein/REAXYS Number:
3900820

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InChI key

AIPNSHNRCQOTRI-UHFFFAOYSA-N

InChI

1S/C22H14O9.3H3N/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31;;;/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31);3*1H3

SMILES string

N.N.N.OC(=O)c1cc(ccc1O)\C(c2ccc(O)c(c2)C(O)=O)=C3/C=CC(=O)C(=C3)C(O)=O

biological source

synthetic

form

powder

color

dark red

mp

220-225 °C (dec.) (lit.)

solubility

water: soluble 100 mg/mL, dark red

λmax

552 nm (λmax: )

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

Quality Level

200

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This Item
A1895C1154N8002
Aurintricarboxylic acid ammonium salt powder

Sigma-Aldrich

A0885

Aurintricarboxylic acid ammonium salt

Aurintricarboxylic acid practical grade, ≥85% (titration), powder

Sigma-Aldrich

A1895

Aurintricarboxylic acid

4-Chloro-7-sulfobenzofurazan ammonium salt

Sigma-Aldrich

C1154

4-Chloro-7-sulfobenzofurazan ammonium salt

Nuclear Fast Red

Sigma-Aldrich

N8002

Nuclear Fast Red

color

dark red

color

red to very dark red, and Red-Brown andBrown-Red

color

brown, light yellow

color

-

form

powder

form

powder

form

powder

form

powder

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

solubility

water: soluble 100 mg/mL, dark red

solubility

1 M NH4OH: 10 mg/mL

solubility

water: 50 mg/mL, clear, dark yellow

solubility

water: soluble 4 mg/mL, dark red to very dark red and red purple

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

Application

Aurintricarboxylic acid ammonium salt has been used as a nuclease inhibitor to study its effects on transfection.

Biochem/physiol Actions

Aurintricarboxylic acid readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca2+ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca2+-activated protease that is activated during apoptosis.

Other Notes

May contain a substantial amount of polymeric material.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN2616
0000371776
0000371776
BCCM5298
0000263232

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Efficient nonviral cutaneous transfection
Glasspool-Malone et al.
Molecular Therapy, 140-146 (2000)
Qiang Peng et al.
PloS one, 7(10), e47273-e47273 (2012-11-03)
Baboons receiving xenogeneic livers from wild type and transgenic pigs survive less than 10 days. One of the major issues is the early development of profound thrombocytopenia that results in fatal hemorrhage. Histological examination of xenotransplanted livers has shown baboon
Moonhee Lee et al.
Neurobiology of aging, 33(10), 2237-2246 (2012-01-06)
Complement plays a vital role in both the innate and adaptive immune systems. It recognizes a target, opsonizes it, generates anaphylatoxins, and directly kills cells through the membrane attack complex (MAC). This final function, which assembles C5b-9(n) on viable cell
Jakyung Yoo et al.
Journal of molecular modeling, 18(4), 1583-1589 (2011-08-02)
DNA methyltransferase 1 (DNMT1) is an emerging target for the treatment of cancer, brain disorders, and other diseases. Currently, there are only a few DNMT1 inhibitors with potential application as therapeutic agents or research tools. 5,5-Methylenedisalicylic acid is a novel
Hui-Chen Hung et al.
The Journal of antimicrobial chemotherapy, 65(4), 676-683 (2010-01-22)
Enterovirus 71 (EV71) causes serious diseases in humans. The aim of this study was to examine the effects of aurintricarboxylic acid (ATA) on EV71 replication and to explore the underlying mechanism. To measure the activity of ATA in inhibiting the
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