A0231

AS 604850

Name: AS 604850
Brand: SIGMA
Price: 3680 CZK

≥98% (HPLC), solid

Synonym(s):

5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, PI3Kγ inhibitor

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5 MG

CZK 3,680.00

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₅F₂NO₄S

CAS Number:

648449-76-7

Molecular Weight:

285.22

NACRES:

NA.77

PubChem Substance ID:

24724381

UNSPSC Code:

12352200

MDL number:

MFCD19705528

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Key Documents

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Quality Level

100

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: >10 mg/mL, H₂O: <2 mg/mL

shipped in

wet ice

storage temp.

2-8°C

SMILES string

FC1(F)Oc2ccc(cc2O1)\C=C3/SC(=O)NC3=O

InChI

1S/C11H5F2NO4S/c12-11(13)17-6-2-1-5(3-7(6)18-11)4-8-9(15)14-10(16)19-8/h1-4H,(H,14,15,16)/b8-4-

InChI key

SRLVNYDXMUGOFI-YWEYNIOJSA-N

Related Categories

Bioactive Small Molecule Inhibitors

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This Item	S0193	SML1731	L4170
Sigma-Aldrich A0231 AS 604850	Sigma-Aldrich S0193 SKF-86002	Sigma-Aldrich SML1731 A64 trifluoroacetate	L4170 LDN-57444
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form solid	form powder	form solid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: >10 mg/mL, H₂O: <2 mg/mL	solubility DMSO: soluble >10 mg/mL	solubility H₂O: 10 mg/mL, clear	solubility DMSO: 16 mg/mL
shipped in wet ice	shipped in -	shipped in -	shipped in -

Biochem/physiol Actions

AS 604850 is a selective PI3Kγ inhibitor

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Bovine colostrum induces the differentiation of human primary keratinocytes.

Daniela Kovacs et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(5), 6302-6321 (2020-03-12)

Bovine colostrum, the first milk secreted by the mammary glands of cows shortly after they have given birth, provides a natural source of bioactive substances helpful to promote tissue development and repair, and to maintain a healthy immune system. Owing

Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

Montserrat Camps et al.

Nature medicine, 11(9), 936-943 (2005-08-30)

Phosphoinositide 3-kinases (PI3K) have long been considered promising drug targets for the treatment of inflammatory and autoimmune disorders as well as cancer and cardiovascular diseases. But the lack of specificity, isoform selectivity and poor biopharmaceutical profile of PI3K inhibitors have

Human dental pulp stem cells derived extracellular matrix promotes mineralization via Hippo and Wnt pathways.

Chatvadee Kornsuthisopon et al.

Scientific reports, 14(1), 6777-6777 (2024-03-22)

Extracellular matrix (ECM) is an intricate structure providing the microenvironment niche that influences stem cell differentiation. This study aimed to investigate the efficacy of decellularized ECM derived from human dental pulp stem cells (dECM_DPSCs) and gingival-derived mesenchymal stem cells (dECM_GSCs)

Control of Glucocorticoid Receptor Levels by PTEN Establishes a Failsafe Mechanism for Tumor Suppression.

Hon Yan K Yip et al.

Molecular cell, 80(2), 279-295 (2020-10-17)

The PTEN tumor suppressor controls cell death and survival by regulating functions of various molecular targets. While the role of PTEN lipid-phosphatase activity on PtdIns(3,4,5)P3 and inhibition of PI3K pathway is well characterized, the biological relevance of PTEN protein-phosphatase activity

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Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Global Trade Item Number

SKU	GTIN
A0231-5MG	04061832433707
A0231-25MG	04061832258058

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AS 604850