The solubility is not tested internally, but literature indicates solubility in aqueous solution up to about 20 g/L. Solution stability information is not available. It would be best to prepare solutions just prior to use, unless a stability study can be performed by the end user.
79849
(±)-Mevalonic acid 5-phosphate lithium salt hydrate
95% (TLC)
Synonym(s):
(±)-MVAP-Li, rac-5-Phosphomevalonate lithium salt
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 10 mg | Please contact Customer Service for Availability | CZK 7,060.00 |
About This Item
Empirical Formula (Hill Notation):
C6H13O7P · xLi+ · yH2O
Molecular Weight:
228.14 (free acid basis)
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
Quality Level
assay
95% (TLC)
form
powder or crystals
relevant disease(s)
Alzheimer′s disease; autoimmune diseases
storage temp.
2-8°C
SMILES string
OC(CC(C)(O)CCOP(O)(O)=O)=O.[H]O[H].[Li+]
InChI
1S/C6H13O7P.3Li.H2O/c1-6(9,4-5(7)8)2-3-13-14(10,11)12;;;;/h9H,2-4H2,1H3,(H,7,8)(H2,10,11,12);;;;1H2/q;3*+1;/p-3
InChI key
VYTYNAKRCDFACM-UHFFFAOYSA-K
Related Categories
1 of 1
This Item | |||
|---|---|---|---|
| assay 95% (TLC) | assay ≥95% (TLC) | assay ≥96.0% (GC) | assay ≥95.0% (TLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. 2-8°C |
| form powder or crystals | form powder | form - | form powder or crystals |
| relevant disease(s) Alzheimer′s disease; autoimmune diseases | relevant disease(s) - | relevant disease(s) - | relevant disease(s) - |
Biochem/physiol Actions
Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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D N Skilleter et al.
The Biochemical journal, 124(2), 407-417 (1971-09-01)
1. Phosphomevalonate kinase and 5-pyrophosphomevalonate decarboxylase have been purified from the freeze-dried latex serum of the commercial rubber tree Hevea brasiliensis. 2. The phosphomevalonate kinase was acid- and heat-labile and required the presence of a thiol to maintain activity. 3.
Li Gong et al.
Cell death & disease, 10(4), 327-327 (2019-04-13)
The mevalonate pathway is known for the synthesis of cholesterol, but recent studies have reported that it also controls Hippo signaling, which is critical for the regulation of organ size and tumorigenesis. Here, we discover that the suppression of the
John L Andreassi et al.
Biochemistry, 48(27), 6461-6468 (2009-06-03)
The galacto-, homoserine-, mevalonate-, phosphomevalonate-kinase (GHMP) superfamily encompases a wide-range of protein function. Three members of the family (mevalonate kinase, phosphomevalonate kinase, and diphosphomevalonate decarboxylase) comprise the mevalonate pathway found in S. pneumoniae and other organisms. We have determined the
Inhibition of hepatic cholesterol biosynthesis by 3,5-dihydroxy-3,4,4-trimethylvaleric acid and its site of action.
F H Hulcher
Archives of biochemistry and biophysics, 146(2), 422-427 (1971-10-01)
Andrew L Olson et al.
Journal of the American Chemical Society, 132(7), 2102-2103 (2010-02-02)
Phosphomevalonate kinase (PMK) catalyzes phosphoryl transfer from adenosine triphosphate (ATP) to mevalonate 5-phosphate (M5P) on the pathway for synthesizing cholesterol and other isoprenoids. To permit this reaction, its substrates must be brought proximal, which would result in a significant and
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C2175-.5MG | 04061832676302 |
| C2175-5MG | 04061832676326 |
| C2175-1MG | 04061833475270 |
| C2175-250UG | 04061832676319 |
| 79849-10MG | 04061832386027 |
| 79849-50MG | 04061832966588 |
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