53886
Tn Antigen
≥99.0% (TLC), powder or crystals
Synonym(s):
GalNac-α-1-O-serine, O-[2-(Acetylamino)-2-deoxy-α-D-galactopyranosyl]-L-serine
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| Size/SKU | Availability | Price |
|---|---|---|
1 mg | Please contact Customer Service for Availability | 10 300,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C11H20N2O8
CAS Number:
Molecular Weight:
308.29
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
MDL number:
10 300,00 CZK
Please contact Customer Service for Availability
Product Name
Tn Antigen, ≥99.0% (TLC)
Quality Segment
assay
≥99.0% (TLC)
form
powder or crystals
storage temp.
−20°C
SMILES string
CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@H](N)C(O)=O
InChI
1S/C11H20N2O8/c1-4(15)13-7-9(17)8(16)6(2-14)21-11(7)20-3-5(12)10(18)19/h5-9,11,14,16-17H,2-3,12H2,1H3,(H,13,15)(H,18,19)/t5-,6+,7+,8-,9+,11-/m0/s1
InChI key
REDMNGDGDYFZRE-WKWISIMFSA-N
General description
Tn antigen is a truncated O-glycan, that is commonly noticed in colorectal cancer (CRC). It is usually expressed at high levels in cancer cells. Tn antigen is small in size and simple in structure. It has a non-physiological glycan structure in humans, hence it may be identified as foreign by the immune system.
Biochem/physiol Actions
Tn antigen stimulates colorectal cancer metastasis through the activation of epithelial-mesenchymal transition, mediated by H-Ras. It acts as a precursor to several significant complex O-glycans. Subpopulations of blood cells in all lineages carrying the Tn antigen results in a hematological disorder called Tn syndrome.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
1 of 1
This Item | |||
|---|---|---|---|
| description ≥99.0% (TLC) | description - | description ≥98% (HPLC) | description 95% |
| assay ≥99.0% (TLC) | assay - | assay ≥98% (HPLC) | assay 95% |
| Quality Level 100 | Quality Level 200 | Quality Level 300 | Quality Level 100 |
| form powder or crystals | form - | form powder | form solid |
| storage temp. −20°C | storage temp. - | storage temp. 2-8°C | storage temp. −20°C |
![Fmoc-Ser[GalNAc(Ac)3-α-D]-OH 95%](/deepweb/assets/sigmaaldrich/product/structures/252/386/8c4549fe-ca62-45cc-b3a5-21b42bdb2b6a/640/8c4549fe-ca62-45cc-b3a5-21b42bdb2b6a.png)
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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