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Aprotinin from bovine lung

Name: Aprotinin from bovine lung
Brand: SIGMA
Price: 2680 CZK

lyophilized, ~80% (HPCE), crystalline (fine), white, ≥3500 U/mg

Synonym(s):

BPTI, Bovine pancreatic trypsin inhibitor, Trasylol, Trypsin inhibitor (basic)

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Size/SKU	Availability	Price
5 mg	Please contact Customer Service for Availability	2 680,00 CZK
25 mg	Please contact Customer Service for Availability	8 370,00 CZK
100 mg	Please contact Customer Service for Availability	22 900,00 CZK

About This Item

Empirical Formula (Hill Notation):

C₂₈₄H₄₃₂N₈₄O₇₉S₇

CAS Number:

9087-70-1

Molecular Weight:

6511.44

UNSPSC Code:

12352202

NACRES:

NA.26

EC Number:

232-994-9

MDL number:

MFCD00130541

eCl@ss:

32190102

Form:

crystalline (fine)

Assay:

~80% (HPCE)

Biological source:

bovine lung

Mol wt:

~6,500

2 680,00 CZK

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Properties

biological source

bovine lung

Quality Segment

200

assay

~80% (HPCE)

form

crystalline (fine)

quality

lyophilized

specific activity

≥3500 U/mg

mol wt

~6,500

technique(s)

electrophoresis: suitable

color

white

input

mammalian sample(s)

solubility

phosphate buffer: 5 mg/mL, clear, colorless (PH 7.6 (70 mm phosphate))

UniProt accession no.

P00974

storage temp.

2-8°C

SMILES string

S1SCC2NC(=O)CNC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C5NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C9N(CCC9)C(=O)CNC(=O)C(NC(=O)C(NC(=O)C%11N(CCC%11)C(=O

InChI

1S/C284H432N84O79S7/c1-21-144(9)222-271(439)337-174(68-46-105-309-282(300)301)239(407)340-187(120-160-77-85-164(374)86-78-160)251(419)341-185(116-156-55-29-24-30-56-156)250(418)342-188(121-161-79-87-165(375)88-80-161)252(420)346-191(123-208(291)378)246(41

InChI key

ZPNFWUPYTFPOJU-UHFFFAOYSA-N

Gene Information

cow ... PTI(404172)

Description

Application

Aprotinin is largely used as an inhibitor of trypsin.

Biochem/physiol Actions

Aprotinin is a competitive serine protease inhibitor that forms stable complexes with and blocks the active sites of enzyme. This binding is reversible, and most aprotinin-protease complexes will dissociate at extreme pH levels >10 or <3. Structurally, Aprotinin is a monomeric globular protein derived from bovine lung that consists of 58 amino acids, arranged in a single polypeptide chain with three crosslinking disulfide bridges.

Other Notes

1 U corresponds to 1 biological kallikrein inhibitor unit (KIU)

One Trypsin Inhibitor Unit (TIU) will decrease the activity of two trypsin units by 50%, where one trypsin unit will hydrolyze 1.0 μmole of N-alpha-benzoyl-DL-arginine p-nitroanilide per minute at pH 7.8 and 25°C. Another commonly used unit is the KIU, with 1 TIU = 1,300 KIU.

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This Item	A3428	A4529	Y0001154
Sigma-Aldrich 10820 Aprotinin from bovine lung	Sigma-Aldrich A3428 Aprotinin from bovine lung	Sigma-Aldrich A4529 Aprotinin from bovine lung	Y0001154 Aprotinin for system suitability
description lyophilized, ~80% (HPCE), crystalline (fine), white, ≥3500 U/mg	description lyophilized powder, 3-8 TIU/mg solid, BioReagent, suitable for cell culture	description lyophilized powder, 3-7 TIU/mg solid	description European Pharmacopoeia (EP) Reference Standard
assay ~80% (HPCE)	assay -	assay -	assay -
biological source bovine lung	biological source bovine lung	biological source bovine lung	biological source -
technique(s) electrophoresis: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) -	technique(s) -
form crystalline (fine)	form lyophilized powder	form lyophilized powder	form -
mol wt ~6,500	mol wt ~6,500	mol wt ~6,500	mol wt -
solubility phosphate buffer: 5 mg/mL, clear, colorless (PH 7.6 (70 mm phosphate))	solubility H₂O: 5 mg/mL	solubility H₂O: >10 mg/mL	solubility -

Storage Class

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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