10817

Apolipoprotein A-I from human plasma

≥90% (GE)

• Synonym(s): Apo A-1
• UNSPSC Code: 12352202
• NACRES: NA.61
• MDL number: MFCD00132610
• Form: lyophilized solid
• Assay: ≥90% (GE)
• Biological source: human plasma

Properties

• biological source: human plasma
• assay: ≥90% (GE)
• form: lyophilized solid
• solubility: H₂O: 1 mg/mL, clear, colorless
• UniProt accession no.: P02647
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... APOA1(335)

Description

General description

Apolipoprotein A-I (apoA-I) is the chief protein component of high density lipoproteins (HDL) and a major determinant of HDL structure, composition, and stability. It is an exchangeable apolipoprotein and plays pivotal role in the metabolism of cholesterol. [1]

Application

Apolipoprotein A-I (apoA-I) was used for protecting the heart against vascular disease, it also protects other vascular beds and organs.[2] It was protective against atherosclerosis through its ability to intervene in reverse cholesterol transport.[3]

Biochem/physiol Actions

High-density lipoproteins are antiatherogenic and cardioprotective by facilitating reverse cholesterol transport (RCT). Some strategies for elevating apolipoprotein A-I levels are studied as therapies for atherosclerosis.

Preparation Note

lyophilized from 0.01 M ammonium hydrogen carbonate

Other Notes

A principal protein component of high-density lipoproteins. Protein - lipid interactions

Safety Information

• Storage Class: 13 - Non Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable