05288

K-252a

from Nocardiopsis sp.

• Synonym(s): Protein kinase inhibitor
• Empirical Formula (Hill Notation): C₂₇H₂₁N₃O₅
• CAS Number: 99533-80-9
• Molecular Weight: 467.47
• NACRES: NA.85
• PubChem Substance ID: 329747678
• UNSPSC Code: 12352200
• MDL number: MFCD00161522
• Form: powder

Properties

• biological source: Nocardiopsis sp.
• form: powder
• antibiotic activity spectrum: viruses
• mode of action: enzyme | inhibits
• storage temp.: −20°C
• SMILES string: [H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
• InChI: 1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1
• InChI key: KOZFSFOOLUUIGY-SOLYNIJKSA-N
• Gene Information: human ... NTRK1(4914) ; rat ... Prkca(24680)

Description

Application

K-252a is used to inhibit protein kinases involved in cell signaling processes, including CaM kinase; phosphorylase kinase, serine/threonine kinases, Trk. It is used to inhibit the actions of nerve growth factor (NGF) on PC1 2 cells and to inhibit smooth muscle myosin light chain kinase .

Biochem/physiol Actions

Potent inhibitor of various protein kinases including protein kinase A, C, and G. It is is reported to selectively inhibit the actions of nerve growth factor (NGF) on PC1 2 cells and has been shown to inhibit smooth muscle myosin light chain kinase .

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H360D,H371
• pcodes: P202 - P260 - P264 - P280 - P308 + P311 - P405
• Hazard Classifications: Repr. 1B - STOT SE 2
• target_organs: Eyes,Central nervous system
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges