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366927

Sigma-Aldrich

Chloroform

suitable for HPLC, ≥99.8%, contains 0.5-1.0% ethanol as stabilizer

Synonym(s):

Methylidyne trichloride, Trichloromethane

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About This Item

Empirical Formula (Hill Notation):
CHCl3
CAS Number:
67-66-3
Molecular Weight:
119.38
Beilstein:
1731042
MDL number:
MFCD00000826
UNSPSC Code:
12190000
PubChem Substance ID:
329755457
NACRES:
NA.04

vapor density

4.1 (vs air)

Quality Level

100

vapor pressure

160 mmHg ( 20 °C)

Assay

≥99.8%

form

liquid

purified by

glass distillation

contains

0.5-1.0% ethanol as stabilizer

technique(s)

HPLC: suitable

impurities

Acetone and aldehyde, passes test
 Acid and chloride, passes test
 Free chlorine (Cl), passes test
 H2SO4, passes test (darkened)
≤0.01% water

evapn. residue

<0.0003%

color

APHA: ≤10

refractive index

n20/D 1.445 (lit.)

bp

60.5-61.5 °C (lit.)

mp

−63 °C (lit.)

density

1.48 g/mL at 25 °C
1.492 g/mL at 25 °C (lit.)

cation traces

Pb: ≤0.05 ppm

λ

H2O reference

UV absorption

λ: 245 nm Amax: 1.00
λ: 255 nm Amax: 0.15
λ: 260 nm Amax: 0.15
λ: 270 nm Amax: 0.02
λ: 290 nm Amax: 0.01
λ: 400 nm Amax: 0.01

suitability

passes test for HPLC

storage temp.

room temp

SMILES string

ClC(Cl)Cl

InChI

1S/CHCl3/c2-1(3)4/h1H

InChI key

HEDRZPFGACZZDS-UHFFFAOYSA-N

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Application


  • Novel Approaches for the Analysis and Isolation of Benzylisoquinoline Alkaloids in Chelidonium majus.: This study presents innovative methodologies using chloroform in the extraction and analysis processes, highlighting advances in alkaloid chemistry (Ganzera et al., 2024).

  • Antioxidant, anti-amylase, anti-lipase, and efficiency of Satureja fatty acid on the anti-inflammatory parameters in lipopolysaccharide-stimulated macrophage through Nrf2/NF-kB/NADH oxidase pathway.: Although primarily focused on biological assays, this paper includes essential methodologies employing chloroform for the extraction and purification of biochemical compounds (Saharkhiz MJ et al., 2024).

  • Recent additions and access to a multidimensional lipidomic database containing liquid chromatography, ion mobility spectrometry, and tandem mass spectrometry information.: Chloroform is utilized as a key solvent in the extraction and analysis processes within lipidomics, demonstrating its critical role in modern analytical techniques (Baker ES et al., 2024).

  • Preparation and optimization of dummy molecularly imprinted polymer-based solid-phase extraction system for selective enrichment of p-toluene sulfonate esters genotoxic impurities.: The study includes the use of chloroform in the preparation of polymers for advanced chromatographic applications, illustrating its versatility in analytical methodologies (Shan G et al., 2024).



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Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Target Organs

Central nervous system, Liver,Kidney

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

does not flash

Flash Point(C)

does not flash

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