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P2698000

Prednicarbate

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(11β)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-21-(1-oxopropoxy)pregna-1,4-diene-3,20-dione

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About This Item

Empirical Formula (Hill Notation):
C27H36O8
CAS Number:
73771-04-7
Molecular Weight:
488.57
EC Number:
277-590-3
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

prednicarbate

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

InChI

1S/C27H36O8/c1-5-22(31)34-15-21(30)27(35-24(32)33-6-2)12-10-19-18-8-7-16-13-17(28)9-11-25(16,3)23(18)20(29)14-26(19,27)4/h9,11,13,18-20,23,29H,5-8,10,12,14-15H2,1-4H3

InChI key

FNPXMHRZILFCKX-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Prednicarbate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

Y0001630

Prednicarbate for system suitability A, European Pharmacopoeia (EP) Reference Standard

1554909

Prednicarbate, United States Pharmacopeia (USP) Reference Standard

1554910

Prednicarbate Related Compound A, United States Pharmacopeia (USP) Reference Standard

1554931

Prednicarbate Related Compound C, United States Pharmacopeia (USP) Reference Standard

1554920

Prednicarbate Related Compound B, United States Pharmacopeia (USP) Reference Standard

Y0002231

Prednicarbate for peak identification, CRS, European Pharmacopoeia (EP) Reference Standard

PHR3101

Prednicarbate, pharmaceutical secondary standard, certified reference material

PHR3102

Prednicarbate Related Compound C, pharmaceutical secondary standard, certified reference material

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360D

Precautionary Statements

P201 - P280 - P308 + P313

Hazard Classifications

Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

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I Spika et al.
Skin pharmacology and applied skin physiology, 16(3), 143-150 (2003-04-05)
As compared to standard glucocorticoids (GC), prednicarbate (PC) is favorable in the treatment of eczema due to its high benefit/risk ratio. The remarkable anti-inflammatory effects of PC are in strong contrast to its reported low glucocorticoid receptor (GR) binding affinity.
V Niemeier et al.
The Journal of dermatological treatment, 16(2), 95-101 (2005-07-16)
The treatment of atopic dermatitis still remains a challenge. Little research has been done on the issue of the extent to which patients correctly use prescribed topical preparations under everyday conditions. To investigate what quantity of topical preparations is applied
Aditya K Gupta et al.
Journal of cutaneous medicine and surgery, 8(4), 244-247 (2005-08-11)
Topical steroids have been a popular choice for treating various cutaneous disorders; however, the potential for significant local and systemic adverse events, like skin atrophy and hypothalamic-pituitary-adrenal (HPA) axis suppression, has limited their use. This article reviews the topical steroid
Aditya K Gupta et al.
Journal of drugs in dermatology : JDD, 3(5), 553-556 (2004-11-24)
Prednicarbate is a non-halogenated, double-ester derivative of prednisolone that has become of interest for the treatment of inflammatory skin diseases, for example atopic dermatitis. In the past, topical steroids have been a popular choice for treating these diseases; however, the
Grover's disease associated with pregnancy.
Eui Hyung Lee et al.
The Journal of dermatology, 37(4), 381-383 (2010-05-29)
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