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A5000

Acetaminophen

meets USP testing specifications, 98.0-102.0%, powder

Synonym(s):

4′-Hydroxyacetanilide, 4-Acetamidophenol, N-(4-Hydroxyphenyl)acetamide, N-Acetyl-4-aminophenol, APAP, Paracetamol

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Pack SizeSKUAvailabilityPrice
100 g
Please contact Customer Service for Availability
CZK 1,330.00
500 g
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CZK 4,550.00
1 kg
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CZK 4,590.00

About This Item

Linear Formula:
CH3CONHC6H4OH
CAS Number:
103-90-2
Molecular Weight:
151.16
UNSPSC Code:
12352111
NACRES:
NA.25
PubChem Substance ID:
24890930
MDL number:
MFCD00002328
Beilstein/REAXYS Number:
2208089
Assay:
98.0-102.0%
Form:
powder
Quality level:
200

CZK 1,330.00

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Quality Level

200

agency

USP/NF, meets USP testing specifications

assay

98.0-102.0%

form

powder

mp

168-172 °C (lit.)

solubility

DMSO: 5 M, ethanol: 50 mg/mL, H2O: very slightly soluble

application(s)

pharmaceutical (small molecule)

SMILES string

CC(=O)Nc1ccc(O)cc1

InChI

1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)

InChI key

RZVAJINKPMORJF-UHFFFAOYSA-N

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Show Differences

1 of 1

This Item
PHR1005A-064Y0001781
Acetaminophen meets USP testing specifications, 98.0-102.0%, powder

Sigma-Aldrich

A5000

Acetaminophen

Acetaminophen Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1005

Acetaminophen

Acetaminophen solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

A-064

Acetaminophen solution

Paracetamol for equipment qualification European Pharmacopoeia (EP) Reference Standard

Y0001781

Paracetamol for equipment qualification

assay

98.0-102.0%

assay

-

assay

-

assay

-

form

powder

form

-

form

liquid

form

-

Quality Level

200

Quality Level

300

Quality Level

300

Quality Level

-

solubility

DMSO: 5 M, H2O: very slightly soluble, ethanol: 50 mg/mL

solubility

-

solubility

-

solubility

-

agency

USP/NF

agency

traceable to BP 371, traceable to Ph. Eur. P030000, traceable to USP 1003009

agency

-

agency

-

mp

168-172 °C (lit.)

mp

168-172 °C (lit.)

mp

-

mp

168-172 °C (lit.)

Application

Analgesic.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

flash_point_f

364.3 °F - Pensky-Martens closed cup

flash_point_c

184.6 °C - Pensky-Martens closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX1247
MKCV4785
MKCT8276
MKCT3819
MKCS3304

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Mohammad A Rahman et al.
Scientific reports, 9(1), 6571-6571 (2019-04-27)
Cellular CYP2E1 is well-known to mediate alcohol- (ALC) and acetaminophen- (APAP) induced toxicity in hepatic and extra-hepatic cells. Although exosomes have been gaining importance in understanding mechanism of intra- and inter-cellular communication, the functional role of drug metabolizing cytochrome P450
Mitchell R McGill et al.
Pharmaceutical research, 30(9), 2174-2187 (2013-03-07)
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular necrosis in the liver. The first studies of APAP metabolism and activation were published more than 40 years ago.
Garry G Graham et al.
Inflammopharmacology, 21(3), 201-232 (2013-05-31)
Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors. Paracetamol is, on average, a weaker analgesic than NSAIDs or COX-2 selective
Garry G Graham et al.
Drug safety, 28(3), 227-240 (2005-03-01)
The excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major factor in the very wide use of the drug. The major problem in the use of paracetamol is its hepatotoxicity after an overdose. Hepatotoxicity has also been reported
Karel Allegaert et al.
Archives of disease in childhood, 98(6), 462-466 (2013-04-23)
There remains a need for alternative medical treatments for patent ductus arteriosus (PDA) closure in extreme preterm neonates because of therapeutic failure and adverse effects associated with non-selective cyclo-oxygenase inhibitors. Reports of an association between paracetamol exposure and PDA closure
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Global Trade Item Number

SKUGTIN
A5000-1KG04061833375303
A5000-500G04061833375310
A5000-100G04061835542192

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Could we know the approximate size range of the acetaminophen (Product number: A5000) powder particles?

    1 answer

    1. This product is not tested for particle size. The material is sieved and the majority of particles fall through a 100-mesh sieve, indicating the bulk is smaller than 150 microns.

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