The concentration of this product can be determined using the lot specific purity reported in the Certificate of Analysis, the density, and the compound molecular weight. This product has a density of 0.815 g/mL and a molecular weight of 126.20 g/mol. The minimum purity is 98.0%, thus the molarity will vary slightly from lot to lot. The molarity can range from 6.33M (98.0%) to 6.46M (100%).
38370
DIC
≥98.0% (GC), for peptide synthesis
Synonym(s):
N,N′-Diisopropylcarbodiimide
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25 ML
CZK 2,290.00
100 ML
CZK 5,730.00
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CZK 21,600.00
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25 ML
CZK 2,290.00
100 ML
CZK 5,730.00
500 ML
CZK 21,600.00
About This Item
Linear Formula:
(CH3)2CHN=C=NCH(CH3)2
CAS Number:
Molecular Weight:
126.20
Beilstein:
878281
EC Number:
MDL number:
UNSPSC Code:
12352001
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Product Name
DIC, purum, ≥98.0% (GC)
grade
purum
Quality Level
Assay
≥98.0% (GC)
form
liquid
reaction suitability
reaction type: Coupling Reactions
refractive index
n20/D 1.433 (lit.)
bp
145-148 °C (lit.)
density
0.815 g/mL at 20 °C (lit.)
0.815 g/mL at 20 °C
application(s)
peptide synthesis
functional group
amine
SMILES string
CC(C)N=C=NC(C)C
InChI
1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3
InChI key
BDNKZNFMNDZQMI-UHFFFAOYSA-N
Gene Information
human ... EPHX2(2053)
mouse ... Ephx2(13850)
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General description
N,N′-Diisopropylcarbodiimide (DIC) is a carbodiimide used as a coupling reagent in the synthesis of amides, peptides, ureas, heterocycles, and unsymmetrical carbodiimides. It is also used in the polymerization reactions as an activator.[1]
Application
N,N′-Diisopropylcarbodiimide can be used:
- To synthesize lanthanide (Ln) guanidinate complexes via insertion of carbodiimide into the Ln-N bond of lanthanocene secondary amido complexes.[2]
- To facilitate the cyclization of N-(β-Hydroxy)amides to form 2-oxazolines.[3]
- To synthesize 1-isopropyl-2-alkoxycarbonyl-3-isopropyliminio-aziridine by reacting with alkyl diazoacetates in the presence of transition metal salts.[4]
DIC can be used as:
- A coupling reagent for the synthesis of various esters and amides by treating carboxylic acids with phenols and amines respectively.[5]
- A reagent for the conversion of alcohols to aldehydes or ketones in the presence of DMSO via modified Moffatt-type oxidation reaction.[1]
- A reagent to facilitates the preparation of alkyl halides from corresponding alcohols via the formation of o-alkylisourea.[6]
Alternative to dicyclohexylcarbodiimide in peptide synthesis.
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Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 1 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Resp. Sens. 1 - Skin Sens. 1
Storage Class Code
3 - Flammable liquids
WGK
WGK 3
Flash Point(F)
91.4 °F
Flash Point(C)
33 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Alcohols can be converted in high yields to the corresponding alkyl halides in a one-pot procedure via the corresponding O-alkylisourea; very short reaction times are possible when microwave irradiation is used.
1, 3-Diisopropylcarbodiimide
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Amidation and esterification of carboxylic acids with amines and phenols by N, N?-diisopropylcarbodiimide: A new approach for amide and ester bond formation in water
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Organometallics, 23(13), 3303-3308 (2004)
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