NXF-10
Natrix® Q Pilot
Synonym(s):
Natrix® Q Membrane Adsorber
About This Item
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ligand
quaternary amine
Quality Level
description
Natrix® Q Pilot
product line
Natrix®
parameter
75-375 mL/min flow rate
bed H
0.5 mm
bed volume
15 mL
matrix active group
Macroporous polymer
pore size
0.4 μm pore size
capacity
3 g binding capacity (BSA)(per device)
separation technique
strong anion exchange
shipped in
ambient
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General description
Natrix®(Q)chromatography membrane is a high productivity strong anion exchange membrane designed for biomolecule purification. The unique Natrix®(Q)chromatography membrane is a porous polyacrylamide hydrogel containing a high density of pendant quaternary ammonium™(Q) binding groups that are directly polymerized within the an inert, macroporous membrane scaffold. The interconnected pore structure and high functional group density enables fast flow rates (seconds of residence time) with impressive throughput to extremely high loads while maintaining excellent impurity reduction across a wide range of buffer conditions. The Natrix®(Q)chromatography membrane design delivers improvements in productivity, flexibility, and process robustness and economics for any bioprocess design. The Natrix®(Q) Pilot is an intermediate scale device, intended to verify and adjust operating parameters. The Pilot may be used for small-scale clinical and commercial manufacturing.
mAb nominal polishing capacity: 150 g
Membrane configuration: Pleated
1 device per package
Features and Benefits
- High density of quaternary amine binding sites enabling rapid mass transfer
- High binding capacity even at fast flow rates
- Combination of performance and speed in, single use, plug-and-play device format enables low risk, scalable solutions for efficient biomolecule purification.
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