Mutations in the PTEN-induced kinase 1 (PINK1) gene located within the PARK6 locus on chromosome 1p35-p36 have recently been identified in patients with recessive early-onset Parkinson disease. Data suggests that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance.
Specificity
This antibody recognizes PINK1.
Application
This Anti-PINK1 Antibody, clone N4/49 is validated for use in IH, WB for the detection of PINK1.
Western Blot Analysis: A previous lot of MABN18 recognized PINK1 in HEK cells and a rat brain LSP, as reported by an independent laboratory (UC Davis/NIH NeuroMab Facility; www.neuromab.org/[email protected]).
Quality
Evaluated by Immunohistochemistry in human normal brain tissue.
Immunohistochemistry Analysis: A 1:500 dilution of this antibody detected PINK1 in human normal brain tissue.
Target description
63 kDa Observed
Physical form
Format: Purified
Analysis Note
Control Human normal brain tissue
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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