This product may be reconstituted in water to a concentration of 0.1-1.0 mg/mL, do not vortex. For long-term storage, we recommend that the stock solution be further diluted in a buffer containing 0.1% BSA or a similar carrier protein. Store in working aliquots at -20°C to -80°C, and avoid repeated freeze/thaw cycles.
GF168
BMP-6 Protein, Human Recombinant
The Bone Morphogenetic Protein 6 also known as Vgr-1 protein, is one of at least 15 structurally & functionally related BMPs which are members of the TGF-β superfamily.
Synonym(s):
Bone Morphogenetic Protein 6, BMP6, VRR-1, VG-1-related protein
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| Size/SKU | Availability | Price |
|---|---|---|
10 μg | Estimated to ship onJune 10, 2026fromAreál Kühne+Nagel spol. s r.o. | CZK 9,350.00 |
About This Item
UNSPSC Code:
12352202
NACRES:
NA.77
eCl@ss:
32160405
Assay:
>95% (SDS-PAGE and HPLC)
CZK 9,350.00
Estimated to ship onJune 10, 2026Details
General description
Bone Morphogenetic Protein 6 (BMP-6), also known as Vgr-1, is one of at least 15 structurally and functionally related BMPs which are members of the transforming growth factor β (TGF-β) superfamily. TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown. Recombinant human BMP-6 is a 26.2 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, which correspond to amino acid residues 397 to 513 of the full-length BMP-6 precursor.
Product Source: HEK293 Cells
Application
Research Category
Stem Cell Research
Stem Cell Research
Research Sub Category
Growth Factors & Receptors
Growth Factors & Receptors
Biochem/physiol Actions
Cross Reactivty
None
None
Physical form
Product is filtered through a 0.2 micron filter before lyophilization.
Preparation Note
Store at -20°C for up to 6 months from date of receipt.
Analysis Note
Bioactivity assay: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 this effect is 0.03-0.06 μg/ml.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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This Item | |||
|---|---|---|---|
| assay >95% (SDS-PAGE and HPLC) | assay >98% (SDS-PAGE and HPLC) | assay ≥95% (HPLC), ≥95% (SDS-PAGE) | assay - |
| storage temp. -10 to -25°C | storage temp. -10 to -25°C | storage temp. −20°C | storage temp. -10 to -25°C |
| impurities <0.1 μg/mg protein endotoxin (<1EU/μg) | impurities <0.1 μg/mg protein endotoxin (<1EU/μg) | impurities <0.1 EU/μg endotoxin, tested | impurities <0.1 μg/mg protein endotoxin (<1 EU/μg) |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| shipped in dry ice | shipped in dry ice | shipped in wet ice | shipped in dry ice |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level 100 |
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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