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Anti-A20 Mouse mAb (59A426)

Name: Anti-A20 Mouse mAb (59A426)
Brand: MM

liquid, clone 59A426, Calbiochem^®

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About This Item

NACRES:

NA.43

UNSPSC Code:

12352203

Clone:

59A426, monoclonal

Species reactivity:

human

Application:

—

Citations:

Pricing and availability is not currently available.

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biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

59A426, monoclonal

form

liquid

contains

≤0.1% sodium azide as preservative

species reactivity

human

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, avoid repeated freeze/thaw cycles

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This Item	OP133	386032	CC43
Sigma-Aldrich AM63 Anti-A20 Mouse mAb (59A426)	Sigma-Aldrich OP133 Anti-IKKα Mouse mAb (14A231)	Sigma-Aldrich 386032 Anti-Hsp70 Mouse mAb (C92F3A-5)	Sigma-Aldrich CC43 Anti-Cdh1 (Ab-2) Mouse mAb (DH01)
antibody form purified antibody	antibody form affinity isolated antibody	antibody form purified antibody	antibody form purified antibody
Gene Information human ... TNFAIP3(7128)	Gene Information human ... CHUK(1147)	Gene Information human ... HSPA1A(3303)	Gene Information human ... CDH1(999)
species reactivity human	species reactivity monkey, human, mouse	species reactivity -	species reactivity human
clone 59A426, monoclonal	clone 14A231, monoclonal	clone C92F3A-5, monoclonal	clone DH01, monoclonal
biological source mouse	biological source mouse	biological source mouse	biological source mouse
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100

General description

Anti-A20 mouse monoclonal antibody, clone 59A426, recognizes ~70 kDa A20 protein in Daudi cells. It is validated for use in immunoblotting and immunoprecipitation.

Protein G purified mouse monoclonal antibody. Recognizes the ~70 kDa A20 protein.

Recognizes the ~70 kDa A20 protein in Daudi cells.

Immunogen

Human

full-length recombinant human A20 protein

Application

Immunoblotting (1:500-1:2000)
Immunoprecipitation (2 g/mg)

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In PBS, 0.2% gelatin.

Preparation Note

Following initial thaw, aliquot freeze (-20°C).

Analysis Note

Positive Control
Daudi cells

Other Notes

Antibody should be titrated for optimal results in individual systems.

Heyninck, K., et al. J. Cell Biol145, 1471.
May, M.J. et al. 1997. Seminars in Cancer Biology.2, 63.
Tewari, M., et al. 1995. J. Immunol.154, 1699.
Opipari, A.W., et al. 1990. J. Biol. Chem.265, 14705.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation.

Fuminori Tokunaga et al.

The EMBO journal, 31(19), 3856-3870 (2012-10-04)

LUBAC (linear ubiquitin chain assembly complex) activates the canonical NF-κB pathway through linear polyubiquitination of NEMO (NF-κB essential modulator, also known as IKKγ) and RIP1. However, the regulatory mechanism of LUBAC-mediated NF-κB activation remains elusive. Here, we show that A20

ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB.

Minho Won et al.

Cell death and differentiation, 29(6), 1152-1163 (2021-11-29)

In TNF signaling, ubiquitination of RIP1 functions as an early cell-death checkpoint, which prevents the spatial transition of the signaling complex from complex-I to death-inducing complex-II. Here, we report that ankyrin repeat domain 13a (ANKRD13a) acts as a novel component

Global Trade Item Number

SKU	GTIN
AM63-100UG	04055977228021

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