AB1871

Anti-Caspase 1 Antibody

Chemicon^®, from rabbit

• Synonym(s): ICE
• UNSPSC Code: 12352203
• NACRES: NA.41
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IF, IP, WB
• Citations: 29

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity purified immunoglobulin
• antibody product type: primary antibodies
• clone: polyclonal
• purified by: affinity chromatography
• species reactivity: human, rat, mouse
• manufacturer/tradename: Chemicon^®
• technique(s): immunofluorescence: suitable, immunoprecipitation (IP): suitable, western blot: suitable
• NCBI accession no.: NM_001223.3, NM_033292.2, NM_033293.2, NM_033294.2, NM_033295.2
• UniProt accession no.: P29466
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: human ... CASP1(834) ; mouse ... Casp1(12362) ; rat ... Casp1(25166)

Description

General description

Caspase-1 (ICE, interleukin-1b-converting enzyme) is the mammalian caspase responsible for the proteolytic conversion of the proforms of interleukin-1b and IL-18 into active cytokines. Like other caspases, caspase-1 itself is synthesized as a proenzyme that is cleaved during activation into large (20 kDa) and small (10 kDa) subunits.

Application

Western blot: 1-4 μg/mL

Immunoprecipitation: 4-8 μg/mL

Immunofluorescence: 10-20 μg/mL

Optimal working dilutions must be determined by end user.

This Anti-Caspase 1 Antibody is validated for use in IF, IP, WB for the detection of Caspase 1.

Biochem/physiol Actions

AB1871 recognizes the 45 kDa procaspase-1 as well as the 20 kDa cleaved caspase-1.

Physical form

Affinity purified immunoglobulin. Liquid in PBS, pH 7.2, containing 50% glycerol, 1% BSA and 0.02% sodium azide.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 2