8.52244

Fmoc-D-Ser(PO(OBzl)OH)-OH

for peptide synthesis, Novabiochem^®

• Synonym(s): Fmoc-D-Ser(PO(OBzl)OH)-OH, N-α-Fmoc-O-benzyl-D-phosphoserine
• Empirical Formula (Hill Notation): C₂₅H₂₄NO₈P
• Molecular Weight: 497.43
• UNSPSC Code: 12352209
• NACRES: NA.22

Properties

• Product Name: Fmoc-D-Ser(PO(OBzl)OH)-OH, Novabiochem^®
• Quality Segment: 200
• product line: Novabiochem^®
• form: solid
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• functional group: Fmoc
• storage temp.: 15-25°C

Description

General description

An excellent building block for the preparation of D-phosphoserine-containing peptides by Fmoc SPPS. This derivative can be introduced using standard activation methods, such as PyBOP^® and TBTU. The monoprotected phosphoserine residue once incorporated is stable to piperidine. Using this reagent, even peptides containing multiple phosphorylation sites can be prepared efficiently by standard Fmoc SPPS methods.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Peptides containing Post-Translational Modifications

Novabiochem^®

Analysis Note

Colour (visual): white to off white
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in DMF): +9.5 - +12.5 °
Purity (TLC(CMA1)): ≥ 97 %
Assay (HPLC, area%): ≥ 95.0 %
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 90.0 %
Water (K. F.): ≤ 2.0 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Other Notes

Replaces: 04-13-1078

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable